Singh Alok

About

I am Senior Research Investigator at the Perelman School of Medicine at UPenn. My ongoing investigations include solid tumor immunotherapy targeted against bladder cancer.

Employment

• University of Pennsylvania Perelman School of Medicine Senior Research Investigator
  2022 - Present
• Johns Hopkins Medicine Faculty Research Associate
  2020 - 2032
• Johns Hopkins School of Medicine Post-Doctoral Fellow
  2015 - 2020

Education

• Jawaharlal Nehru University School of Life Sciences PhD
  2009 - 2014
• University of Calicut M.Sc. (Biotechnology)
  2006 - 2008
• Jai Prakash Vishwavidyalaya B.Sc. (Honors)

Projects & Funding

Projects & funding information is unavailable.

Publications (31)

• Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP
  Microbiology Spectrum 2024 DOI: 10.1128/spectrum.02012-23
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• MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival
  JCI Insight 2023 DOI: 10.1172/jci.insight.166242
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• Intravenous BCG vaccination reduces SARS-CoV-2 severity and promotes extensive reprogramming of lung immune cells
  iScience 2023 DOI: 10.1016/j.isci.2023.107733
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• Abstract A079: Glutamine antagonist prodrug JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancers
  Cancer Research 2023 DOI: 10.1158/1538-7445.prca2023-a079
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• Abstract 6432: Glutamine antagonist prodrug JHU083 reprograms immunosuppressive tumor-associated macrophages (TAMs) to drive tumor immunity in urologic cancers
  Cancer Research 2023 DOI: 10.1158/1538-7445.am2023-6432
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• Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer
  Nature Communications 2022 DOI: 10.1038/s41467-022-28509-z
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• Bcg based vaccine compositions and methods of use thereof
  2022
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• Dynamic single-cell RNA sequencing reveals BCG vaccination curtails SARS-CoV-2 induced disease severity and lung inflammation
  [] 2022 DOI: 10.1101/2022.03.15.484018
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• Recombinant BCGs for tuberculosis and bladder cancer
  Vaccine 2021 DOI: 10.1016/j.vaccine.2021.09.040
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• RECOMBINANT THERAPEUTIC INTERVENTIONS FOR CANCER
  United States Patent Application 20210024940 2021
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