Dangudubiyyam SV

About

My long-term career goal is to become an independent researcher in academia in the field of reproductive physiology with a focus on research to improve maternal and fetal health outcomes. My academic education and research experience have given me strong foundational skills in endocrinology, general reproductive physiology, molecular biotechniques, and cellular signaling mechanisms. I earned a DVM degree from India, where I was exposed to several exciting research directions in various disciplines of veterinary and animal sciences. Throughout my veterinary training, I was particularly intrigued by developments in reproductive physiology and assisted reproductive technologies. Therefore, I decided to pursue an M.S. degree in Animal Reproduction, Gynecology, and Obstetrics. My research utilized sheep as a model species and investigated expression patterns of developmentally essential genes like Kit-Ligand and Bone morphogenetic protein 15 in dissected ovarian follicles. These genes are critical for oocyte development in cultured follicles. Subsequently, I moved to the United States to seek new research opportunities. Initially, I held positions as a research assistant and subsequently research specialist in a bovine reproductive physiology laboratory at the University of Wisconsin-Madison. There I explored endocrine mechanisms driving bovine ovarian follicular dynamics. This work warranted my authorship on 10 peer-reviewed publications. To further advance my career and research training, I enrolled in the Endocrinology and Reproductive Physiology PhD program at the University of Wisconsin-Madison. During my PhD training, I investigated the effects of perfluorooctane sulfonic acid (PFOS) exposure on maternal cardiovascular and placental function using the rat as an animal model. I also investigated the efficacy of Compound 21 (pharmacological agonist) in mitigating PFOS-induced hypertension and collaborated on projects examining the effects of PFOS and hypoxia on metabolic disorders. These graduate training experiences provided me an opportunity to receive excellent mentorship and taught me how to work both independently and with others. Importantly, I developed skills needed to manage my own projects and contribute to collaborative projects. These efforts resulted in the publication of five first-author reports and co-authorship on an additional four reports. To gain the expertise needed for my long-term goal, I am currently pursuing postdoctoral training with Dr. Michael J. Soares at University of Kansas Medical Center, where my research focuses on investigating the molecular mechanisms and signaling pathways regulating placental development and function at the fetal-maternal interface during pregnancy. Specifically, I am exploring the role of a hypoxia inducible factor 2 alpha (HIF2A), encoded by the endothelial PAS domain-containing protein 1 (EPAS1) gene, as a regulator of trophoblast cell development and hemochorial placentation. My research utilizes genetically modified human trophoblast stem cell and rat models, which represent a significant expansion of my current experimental skillset. These skills strengthen my research foundation and will be critical for launching a career as an independent investigator. Successful completion of my postdoctoral research will provide novel insight into the molecular mechanisms and signaling pathways regulating trophoblast cell differentiation and placental development.

Employment

Employment history is unavailable.

Education

• University of Wisconsin-Madison Graduate Research Assistant majoring in Endocrinology and Reproductive Physiology
  2019 - 2024
• Sri Venkateswara Veterinary University Masters of veterinary science (MVSc)
  2008 - 2011
• Rajiv Gandhi Institute of Veterinary Education and Research BVSc & AH
  2002 - 2008

Projects & Funding

Projects & funding information is unavailable.

Publications

Publications are unavailable.