RP

Ramakrishnan Parthasarathi

Also known as: Parthasarathi Ramakrishnan, R Parthasarathi, P Ramakrishnan

Council of Scientific and Industrial Research, CSIR-Indian Institute of Toxicology Research

ORCID iD 0000-0001-5417-5867
Follow

About

Dr Parthasarathi Ramakrishnan, Head, CSIR-HRDG, New Delhi, formerly served as the founding Head of the Computational Toxicology Facility and Technology Development & Innovation Centre (TDIC) at CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow. He has established a dedicated High-Performance Computing facility for toxicology research (TRISHUL) and a translational ecosystem, Technology Development & Innovation Centre (TDIC) at CSIR-IITR. He also led the Centre for Innovation and Translational Research (CITAR)-BIRAC-BIONEST-IITR and DSIR-CRTDH-Environmental Monitoring and Intervention Hub. He earned his PhD from CSIR-CLRI, University of Madras, and has worked as a scientist at Lawrence Berkeley National Labs, Los Alamos National Laboratory, and Sandia National Laboratories in the USA.

With 24+ years of experience across multidisciplinary research areas, he has significantly contributed to unraveling important issues in human health, energy, and the environment. He develops green sustainable solutions, predictive toxicology models, and databases. He has over 150 publications with more than 11,400 citations, an h-index of 54, and 8 patents. He has received several awards, including Cray’s HPC Dr A.P.J. Abdul Kalam Award, Director’s Fellowship, Los Alamos National Laboratory, and Young Associate of the Indian Academy of Sciences. He was elected Fellow of the Royal Society of Chemistry & Indian Chemical Society.

https://scholar.google.co.in/citations?user=aC_1Qc0AAAAJ&hl=en&oi=ao

https://www.researchgate.net/profile/R_Parthasarathi

CURRENT RESEARCH & LABORATORY EXPERIENCE
Currently working in the broad area of research that focuses on fundamental chemical issues and momentous biochemical applications in predictive biology & toxicity.
 Field of Specialization: Computational Chemistry and Biology
 24+ years in Chemistry and Biology research, with a strong record of devising high-impact programs

 Principal Scientist & Sr. Principal Scientist: CSIR-IITR, Lucknow [2016]-
• Developing In Silico Platform for safety/toxicity testing of chemicals, APIs, and drugs
• Database development and dissemination
• Multiscale Modeling - Understanding and predicting the toxicity of biological systems and toxicological pathways using multi-resolution approaches
• Advancing predictive biology using data science and data analytics
 Scientific Lead: The Joint BioEnergy Institute (JBEI), Lawrence Berkeley National Laboratory and Sandia National Laboratories, Emeryville, USA [2012]- [2016]
• Designing and demonstrating bionic solvents for product and process development
• Biomass pretreatment process development using Ionic Liquids (ILs)
• Evaluation of biocompatible and designing Novel Task-Specific ILs
• Developing Structural-Functional Activity Relationships of Enzymes on pretreatment conditions
• MOF catalysis and lignin valorization
• Closed-loop Biorefinery
 Directors Fellow: Los Alamos National Laboratory, Los Alamos, NM, USA
[2009]- [2012]
• Molecular-level studies on overcoming the cell-wall barrier for Biofuels & Chemicals
• Understanding and modulations of Nanomaterial-Biomolecular Interactions
• Computational Nanotoxicology: Toxicity prediction of nanoparticles and nanomaterials
 Postdoctoral Research Associate: Indiana University, Bloomington, IN, USA
Advisor: Professor Krishnan Raghavachari
[2007]-[2009]
• Developed new fundamental mechanistic insights in peptide chemistry, particularly peptide fragmentation under extreme conditions (UV-laser)
• Conformational studies of natural as well as synthetic peptides, therapeutic peptides for medicinal chemistry and drug discovery
 Ph.D.: CSIR-Central Leather Research Institute, Chennai [2001]-[2007]
Advisor: Dr V Subramanian
Associated PIs: Professor N Sathyamurthy, Professor PK Chattaraj, Dr T Ramasami
• Molecular modeling of biomolecules
• Toxicity analysis of various chemical species and carcinogens
• Hydrogen bonding, molecular clusters, and solvation (IIT-Kanpur)
• DFT-based descriptors development for QSAR and applications (IIT-Karagpur),
• Quantum chemistry and molecular dynamics simulations of small molecules, bio-nano macromolecules, and drug design

Employment

  • Council of Scientific and Industrial Research Head
    2025 - Present
  • CSIR-Indian Institute of Toxicology Research Sr Principal Scientist/Head

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (202)