SAMUEL JACOB

About

My high- Impact Educational Practice achieved by teaching and learning from others in the medical field through:
Seminars and sharing experiences, Writing -intensive courses, Capstone courses and projects , lecturing medical student , residents and fellows , supervising research projects. Serve as a peer reviewer for high impact surgical journals. Presenting in international conferences. Testing noble ideas in the lab… etc.
70 % of my time is dedicated to my clinical practice:
1-Heart transplant and circulatory support surgery ,duties involve all aspects of this specialty, including pre-operative, intra-operative, and post-operative management. Pre-operative: heart failure consult, evaluate patients for heart transplant and mechanical support, checking pre-operative investigations, labs, imaging, and catheterization. In addition to participation in selection committee. Intra-operative: participated in a wide range of procedures, such as; ECMO placement in emergency cases, harvesting hearts, implanting left ventricular assisting devices, heart transplant, artificial hearts. In addition to general cardiac surgery procedure; such as Coronary arteries, heart valves, and aortic dissection. Post-operatively: Taking Intensive Care Unit calls on an average of ten days a month, managing ICU issues pertaining to cardiac arrest, intra-aortic balloon placement, managing pacemakers, and ventilation support.
2-Lung Transplant and ECMO Surgery :Respiratory failure consult, evaluation for patients for lung transplant and ECMO support, checking pre-operative investigations, labs, imaging. In addition to participation in selection committee.
Participated in thoracic procedures, such as: ECMO placement in emergency cases, harvesting lungs, and implanting lungs. In addition to general thoracic surgery procedures; such as, VATS, lobectomies, pneumonectomies, esophagectomy , bronchoscopy and lung biopsies.
30 % of my time is spent on research .I am working on multiple research projects such as :
a-Innovative Free-range Resonant Electrical Energy Delivery system (FREE-D System) for a ventricular assist device using wireless power.
Technological innovation of a smaller, single moving part has an advantage over earlier large pulsatile ventricular assist devices (VADs) prone to mechanical failure. Drivelines limit the potential for extended patient survival durations with newer pumps and act as source for infection, increased morbidity, rehospitalizations, and reduced quality of life. The Free-range Resonant Electrical Energy Delivery (FREE-D) wireless power system uses magnetically coupled resonators to efficiently transfer power.

b-Is the heterogenic mother mitochondrial DNA genome a cause of rejection in transplanted organs from cloned animals?
Background: Cloning fully grown species of animals generally uses the somatic cell nuclear transfer (SCNT) technique to create an organism that is genetically identical to the somatic cell donor. This process entails the transfer of a nucleus from an adult donor cell (somatic cell) into an ovum, from which the nucleus has been removed. If the egg begins to divide normally, it is transferred into the uterus of the surrogate mother. Such clones are not strictly identical. The egg cells contain the native mitochondrial DNA in the cytoplasm, thus the mitochondrial genome is not the same as that of the nucleus donor cell from which it was produced. This may have important implications for use of organs from cloned animals in organ transplantation; specifically, nuclear-mitochondrial incompatibilities may lead to organ rejection when organs from cloned animals are used for treating end stage diseases.
Objective: Our objective in this research is to answer a fundamental basic science question: Is the heterogenic mother mitochondrial DNA genome a cause of rejection in transplanted organs from cloned animals?

c-One and a half heart transplant .Novel technique for isolated accessory right heart transplantation for congenital heart disease
Our prior laboratory work has permitted adding a whole donor heart to a preserved recipient right heart, producing a heart-and-a-half preparation able to cope with pulmonary hypertension in the recipient. The experiments in the present study explore the feasibility of the converse operation: adding an isolated donor right heart to an entire preserved heart.

d-EX-VIVO
Shortage of donor organs has increased consideration for use of historically excluded grafts. Ex-vivo machine perfusion is an emerging technology that holds the potential for organ resuscitation and reconditioning, potentially increasing the quality and number of organs available for transplantation.

Employment

• Mayo Clinic Associate Professor of surgery
  2017 - Present

Education

• Baylor University Medical Center Fellow in Heart transplant and mechanical support
  2015 - 2016
• Harvard Medical School fellow in thoracic transplant and ECMO
  2014 - 2015
• Harvard Medical School fellow in cardiac surgery
  2012 - 2014
• Yale School of Medicine transplant research resident
  2011 - 2012
• Advocate Illinois Masonic Medical Center general surgery resident
  2009 - 2011
• Royal College of Surgeons of Edinburgh MRCS. FRCS
  2002 - 2006
• Cambridge University Hospitals NHS Foundation Trust BSS
  2000 - 2002
• National Heart and Lung Institute Division of Cardiovascular Sciences diploma
  1996 - 1997
• Imperial College Healthcare NHS Trust DIC diploma in cardiac surgery
  1995 - 1996
• Damascus University Faculty of Medicine MD
  1984 - 1991

Projects & Funding

Projects & funding information is unavailable.

Publications

Publications are unavailable.