Amber L. Mosley
Also known as: Amber Mosley
Indiana University School of Medicine, Stowers Institute for Medical Research, University of Kentucky
0000-0001-5822-2894
About
The Mosley lab interrogates dynamic cellular processes through the development and application of quantitative proteomics approaches. We are especially interested in quantitative analysis of the fundamental pathways that control cellular signaling in the fundamental processes of RNA transcription, RNA processing, and protein folding working in multiple model systems which span species and disease models. Recent work has had a strong focus in the areas of neurodegenerative disease and cancer related signaling. Dr. Mosley is an expert in biochemistry, molecular biology, mass spectrometry, bioinformatics, genetics, and computational biology, and has successfully applied these approaches to numerous independent and collaborative projects.
Dr. Mosley received her B.S. in Biology and Philosophy from East Tennessee State University in Johnson City, TN. She then move to the University of Kentucky School of Medicine were she did her PhD studies with Sabire Ӧzcan on glucose regulation of gene transcription with a focus on the insulin gene. Amber then worked as a postdoctoral fellow with Michael Washburn at Jerry Workman at the Stowers Institute for Medical Research where she began her training in quantitative proteomics and applied this technology to the study of basic transcription mechanisms including the control of RNA Polymerase II phosphorylation. Dr. Mosley has been a faculty member at the Indiana University School of Medicine since 2010 and is currently a Professor of Biochemistry, Molecular Biology, and Pharmacology with a secondary appointment in Medical and Molecular Genetics. Dr. Mosley also serves as the Director of the IU School of Medicine Center for Proteome Analysis, the IU Simon Comprehensive Cancer Center Proteomics Core, and as the codirector of the Indiana Diabetes Center Data and Analytics Core.
Employment
-
Indiana University School of Medicine Professor2010 - Present
Education
-
Stowers Institute for Medical Research2004 - 2010
-
University of Kentucky PhD1999 - 2004
Projects & Funding
Projects & funding information is unavailable.
Publications (93)
- Cyst fluid proteins stratify malignant risk of intraductal papillary mucinous neoplasm of the pancreas Save
- Proliferative proteome induced by HPV 16E6 and NFX1-123 partnership in longitudinal keratinocyte cultures Save
- VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells Save
- Proximity interactome mapping furthers a role for spinophilin in protein homeostasis Save
- Pancreatic cyst fluid proteins distinguish dysplasia grade of intraductal papillary mucinous neoplasm Save
- PP2A activation drives aberrant macropinocytosis and cell death in pancreatic ductal adenocarcinoma Save
- Characterizing the Molecular Impact of DIS3 Mutation-Driven Mechanisms in Multiple Myeloma Save
- Analytical development and application of a targeted liquid chromatography-tandem mass spectrometry assay for chimeric aducanumab Save
- Alternative splicing of uromodulin enhances mitochondrial metabolism for adaptation to stress in kidney epithelial cells Save
- Activation of PP2A-B56α leads to aberrant EGFR signaling and proliferative phenotypes in PDAC Save