0000-0001-5826-4680 About
I have held the position of Associate Research Scientist at New York University in New York, NY since August 1, 2023. In this role, my research focuses on unraveling the mechanistic basis of trained immunity in innate immune cells.
Prior to this position, I worked as a postdoctoral fellow at NYU Langone Health and the National Institute on Aging (NIA) in Baltimore from November 2019 to July 2023. During my time at NIA, I was responsible for designing and conducting experiments related to various research projects. I also had the opportunity to contribute to the development of grants and the preparation of manuscripts.
My current primary project revolves around gaining a comprehensive understanding of the mechanisms that govern adaptive changes in the heart, specifically in response to the overexpression of the ADCY8 gene within cardiomyocytes. The aim of this project is to gain mechanistic insights into the interplay between the immune system and myocardial pathophysiology.
I earned my doctoral degree in cardiovascular biology from the Rajiv Gandhi Centre for Biotechnology in India in 2019. Throughout my academic journey, I developed a strong foundation in experimental design and laboratory work. I have also achieved success in publishing my research findings in reputable international journals, including eLife, Cell Reports, Nature-Scientific Reports, Heart Failure Reviews, Frontiers in Oncology, and NPJ Systems Biology and Applications.
My overarching career goal is to establish myself as an independent and prominent scientist in the field of biological science, with the ultimate aspiration of leading a research laboratory. In the short term, my research interests are centered on gaining a comprehensive understanding of the regulatory mechanisms underlying immunological signatures within the heart. This includes investigating scenarios of inflammation-driven cellular proliferation and how these alterations impact cardiac and immune cell populations, cardiovascular diseases, and clinical outcomes. To achieve this, it is crucial to develop novel regulatory mechanisms that deepen our understanding of the intricate interactions between the immune system and the heart.
My academic journey has equipped me with a strong technical background for investigating immunological alterations within the heart. I have completed undergraduate and graduate courses (M.Pharm and Ph.D.) that have provided me with the necessary knowledge and hands-on experience in a wide range of techniques, including in-vivo and in-vitro methods. These techniques encompass performing survival surgery in animals (including rats and mice), cell culture, cell transfection, SDS-PAGE, Western Blot, FACS, immunofluorescence, immunoprecipitation, proteomic and metabolomic data analysis, molecular cloning, ELISA, immunohistochemistry, and histology.
I have successfully led and completed Research Topics in Frontiers in Endocrinology, Frontiers in Physiology, and Frontiers in Nephrology, and published an editorial summarizing the contributions. In addition, I actively serve as a peer reviewer for multiple journals, including GeroScience, Heliyon, Frontiers, and Scientific Reports. My research contributions have been published in leading journals such as eLife, Cell Reports, Heart Failure Reviews, Frontiers in Oncology, and NPJ Systems Biology and Applications.
With this background, I bring experience in both authorship and editorial responsibilities, and I am eager to contribute to the scientific community in an editorial capacity by supporting rigorous peer review and advancing high-quality publications.
Employment
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New York University Associate Research Scientist2022 - Present
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NIH-NIA Postdoctoral Fellow2019 - 2023
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Rajiv Gandhi Centre for Biotechnology Research Scholar2014 - 2018
Education
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Rajiv Gandhi Centre for Biotechnology PhD2014 - 2018
Projects & Funding
Projects & funding information is unavailable.
Publications (15)
- Cardiomyocyte-specific adenylyl cyclase type-8 overexpression induces activation of RelA together with myocardial and systemic inflammation Save
- Mitigation of Fibrosis after Myocardial Infarction in Rats by Using a Porcine Cholecyst Extracellular Matrix Save
- A remarkable adaptive paradigm of heart performance and protection emerges in response to the constitutive challenge of marked cardiac-specific overexpression of adenylyl cyclase type 8 Save
- STIL Endows Oncogenic and Stem-Like Attributes to Colorectal Cancer Plausibly by Shh and Wnt Signaling Save
- Mapping drug-target interactions and synergy in multi-molecular therapeutics for pressure-overload cardiac hypertrophy. Save
- Untargeted metabolomics reveals alterations in metabolites of lipid metabolism and immune pathways in the serum of rats after long-term oral administration of Amalaki rasayana Save
- Chronic Pressure Overload Results in Deficiency of Mitochondrial Membrane Transporter ABCB7 Which Contributes to Iron Overload, Mitochondrial Dysfunction, Metabolic Shift and Worsens Cardiac Function Save
- A Splicing-Independent Function of RBM10 Controls Specific 3′ UTR Processing to Regulate Cardiac Hypertrophy Save
- Mitochondrial membrane transporters and metabolic switch in heart failure Save
- Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy Save