MG
Mitchell Gulkis
Howard Hughes Medical Institute, Yale University, University of Florida
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Enzyme Structure and Function · DNA Repair Mechanisms · DNA and Nucleic Acid Chemistry
0000-0001-5831-8802
Employment
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Howard Hughes Medical Institute Postdoctoral Fellow2026 - Present
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Yale University Postdoctoral Fellow2026 - Present
Education
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University of Florida PhD - Biochemistry and Molecular Biology (Expected)2021 - 2025
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University of Florida B.S. - Biochemistry2017 - 2021
Projects & Funding
Projects & funding information is unavailable.
Publications (11)
- AAV2 Crosslinks Actin Filaments: Implications for AAV Gene Therapy Vector Design Save
- Design, anticancer activity, and mechanistic evaluation of a novel class of selective human carbonic anhydrase IX inhibitors featuring a trifluorodihydroxypropanone pharmacophore Save
- Off-target binding of the histone deacetylase inhibitor vorinostat to carbonic anhydrase II and IX Save
- Impact of DNA ligase inhibition on the nick sealing of polβ nucleotide insertion products at the downstream steps of base excision repair pathway. Save
- Probing the mechanism of nick searching by LIG1 at the single-molecule level. Save
- Structural Characterization of Human Bufavirus 1: Receptor Binding and Endosomal pH-Induced Changes Save
- Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA Save
- Unfilled gaps by polβ lead to aberrant ligation by LIG1 at the downstream steps of base excision repair pathway. Save
- Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in the Base Excision Repair Pathway Save
- Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents. Save
- Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair Save