Mikael Marttinen

About

I am interested in translating neurological disease risk variants to phenotypic outcomes by use and development of single-cell and spatial assays paired with integrative computational approaches.

Education:

* 2019-2023: Postdoc at EMBL, Heidelberg | Structural and Computational Biology Unit and Genome Biology Unit

* 2014-2018: PhD University of Eastern Finland | Molecular Medicine

* 2008-2014: MSc in Biosciences | University of Eastern Finland

Positions:
*2026-2031, Assistant Professor (tenure track), Tampere University, Finland
* 2026-2029, Senior Cancer researcher, Finnish Cancer Institute, Finland
* 2025-2026, Senior research fellow, Tampere University, Finland
* 2022-2025 Research Council of Finland Postdoctoral Researcher | Tampere University, Finland
* 2022- Visiting Postdoctoral fellow | European Molecular Biology Laboratory, Heidelberg, Germany
* 2019 - 2022 Postdoctoral fellow | European Molecular Biology Laboratory, Heidelberg, Germany
* 2018 - 2019 Postdoctoral fellow | University of Eastern Finland, Finland
* 2014 - 2018 PhD student | University of Eastern Finland, Finland

Funding:

* 2026, Research Council of Finland, Project Fund
* 2025, Juselius 1-3 year Junior PI grant
* 2025, Instrumentarium Science Foundation fellow
* 2022 Research council of Finland Postdoctoral fellow
* 2021 Instrumentarium foundation Postdoctoral fellowship
* 2019 Sigrid Juselius Foundation Postdoctoral fellowship



Employment

• Tampere University Assistant Professor (tenure track)
  2026 - 2031
• Finnish Cancer Institute Senior Cancer Researcher
  2026 - 2029
• Tampere University Senior research fellow
  2025 - 2026
• European Molecular Biology Laboraty Visiting fellow
  2022 - 2027
• Tampere University Postdoctoral fellow (Academy of Finland)
  2022 - 2025
• European Molecular Biology Laboratory Postdoctoral researcher
  2019 - 2022

Education

• Univeristy of Eastern Finlanf PhD
  2014 - 2018
• University of Eastern Finland MSc
  2008 - 2014

Projects & Funding

Projects & funding information is unavailable.

Publications (31)

• AR suppression rewires a SOX4 regulatory program to promote enzalutamide resistance in prostate cancer
  2026 0 citations DOI: 10.64898/2026.04.27.721035
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• Functional phenotyping of genomic variants using joint multiomic single-cell DNA–RNA sequencing
  Nature Methods 2025 21 citations DOI: 10.1038/s41592-025-02805-0
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• High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes
  2025 1 citation DOI: 10.1101/2025.06.13.659629
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• Functional phenotyping of genomic variants using multiomic scDNA-scRNA-seq
  2024 4 citations DOI: 10.1101/2024.05.31.596895
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• A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease
  Molecular therapy : the journal of the American Society of Gene Therapy 2024 26 citations DOI: 10.1016/j.ymthe.2024.08.022
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• Immunosuppression in the prostate tumor microenvironment is tied to androgen deprivation therapy-resistant club-like cells
  bioRxiv 2024 1 citation DOI: 10.1101/2024.03.25.586330
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• HIPSD&R-seq enables scalable genomic copy number and transcriptome profiling
  bioRxiv 2023 1 citation DOI: 10.1101/2023.10.09.561487
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• Light-Induced Nanoscale Deformation in Azobenzene Thin Film Triggers Rapid Intracellular Ca2+ Increase via Mechanosensitive Cation Channels
  Advanced Science 2023 8 citations DOI: 10.1002/advs.202206190
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• Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
  Neurobiology of Disease 2023 23 citations DOI: 10.1016/j.nbd.2023.106140
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• Scalable ultra-high-throughput single-cell chromatin and RNA sequencing reveals gene regulatory dynamics linking macrophage polarization to autoimmune disease
  bioRxiv 2023 5 citations DOI: 10.1101/2023.12.26.573253
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