Tricia Tan
Imperial College London, North West London Pathology, University of Manchester, Endocrine Supraregional Assay Service for Gut Hormones, University of St Andrews
Research areas: Medicine · Endocrinology, Diabetes and Metabolism · Diabetes Treatment and Management · Bariatric Surgery and Outcomes · Regulation of Appetite and Obesity
0000-0001-5873-3432
About
Prof Tricia Tan (BSc MB ChB FRCP PhD FRCPath) is a Professor of Metabolic Medicine and Endocrinology at Imperial College London. She graduated from the University of St Andrews in 1993 and qualified in medicine from the University of Manchester in 1996. She trained in Diabetes and Endocrinology in London and studied with Prof Stephen Bloom for her doctoral research on gut hormone physiology. Her research, funded by the Wellcome Trust, MRC, NIHR and Imperial BRC, has concentrated on characterizing the physiological effects of human gut hormones on appetite, energy expenditure and glucose homeostasis. A major second theme has been the rational design of gut hormone analogues for therapy of obesity and diabetes, and early Phase clinical trials. Her clinical interests lie in the treatment of obesity with bariatric surgery, and the diagnosis and management of neuroendocrine tumours. She is the Director of the UK Supraregional Assay Service Endocrine Laboratory for Gut Hormones, and serves as the Clinical Lead, Biochemistry, for North West London Pathology Consortium.
Employment
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Imperial College London Professor of Metabolic Medicine and Endocrinology2022 - Present
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Imperial College Healthcare NHS Trust Professor of Practice2018 - 2022
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North West London Pathology Clinical Lead2016 - Present
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Endocrine Supraregional Assay Service for Gut Hormones Director2015 - Present
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Imperial College Healthcare NHS Trust Consultant2008 - Present
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Imperial College London Clinical Research Fellow2007 - 2008
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Hammersmith Hospital Locum Consultant2007 - 2007
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North Central London Training Rotation Specialist Registrar2000 - 2007
Education
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Imperial College London Ph.D.2011 - 2014
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University of Manchester M.B. Ch.B.1993 - 1996
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University of St Andrews B.Sc.1990 - 1993
Projects & Funding
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Investigating the outcomes of pregnancy after metabolic surgery: is sleeve gastrectomy better than gastric bypass? Diabetes UK2023 - 2027
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Building research capacity with high-throughput Ultra-performance liquid chromatography high resolution Q-TOF Medical Research Council2022 - 2023
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How does both glucose-dependent insulinotropic polypeptide (GIP) agonism and GIP antagonism result in protection from diet induced obesity (DIO)? Medical Research Council2021 - 2025
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The effects of PP 1420 on Hepatic Insulin Sensitivity in Pancreatogenic Diabetes: New Hope for a Neglected Disease Moulton Charitable Foundation2017 - 2020
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Metabolism and Endocrinology Theme National Institute for Health Research2017 - 2022
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Are gut hormone changes why the long-limb gastric bypass is more effective than the standard-limb gastric bypass in improving type 2 diabetes mellitus? National Institute for Health Research2015 - 2019
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GLP-1 Receptor Agonist intervention for poor responders after bariatric Surgery Moulton Charitable Foundation2014 - 2017
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Next generation Y analogue for treatment of obesity UKRI Medical Research Council2014 - 2018
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Treatment of obesity with the pancreatic polypeptide analogue PP 1420 Wellcome Trust2013 - 2016
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Developmental Clinical Studies - Curing Obesity with the 'Medical Bypass' Medical Research Council2013 - 2019
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Do gut hormones mediate the beneficial effects of Roux-en-Y bypass surgery? Medical Research Council2013 - 2018
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Developmental Clinical Studies - Phase 1 studies on an analogue of peptide YY as a treatment for obesity UKRI Medical Research Council2011 - 2013
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How the hormones glucagon and GLP-1 control the body’s use of energy Imperial College Healthcare Charity2010 - 2011
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Treatment of obesity by long acting analogues of peptide YY (PYY) UKRI Medical Research Council2009 - 2011
Publications (388)
- Obesity medications versus metabolic bariatric surgery: the debate goes on Save
- A metabolic comparison of GIPR agonism versus GIPR antagonism in male mice Save
- Acute Effects of Acarbose and Canagliflozin, Alone and in Combination, on PostprandialGLP-1 and Glycaemic Responses in Post-Bariatric Hypoglycaemia: A Randomised Crossover Study Save
- Associations Between Weight Loss Prior to Knee and Hip Arthroplasty and Peri- and Post-Operative Outcomes: A Systematic Review and Meta-Analysis Save
- Baseline Mental Health Status and Early Psychiatric Outcomes after Metabolic-Bariatric Surgery: A Retrospective Cohort Study Save
- Comparing the utility of the oral glucose tolerance test in diagnosing gestational diabetes in pregnancy after bariatric surgery Save
- Cortisol and stress levels in women with functional hypothalamic amenorrhoea (FHA) and polycystic ovary syndrome (PCOS) Save
- Dynamic endocrine responses to kisspeptin to decode hypothalamic-pituitary dysfunction in women with obesity Save
- Early changes in circulating immune cell populations following GLP-1 receptor agonist therapy in obesity Save
- Glucagon-Like Peptide-1 Receptor Agonists in Pregnancy: Periconception Exposure and Perinatal Outcomes Save
- Glucocorticoid-induced adrenal insufficiency: physiological dose tapering promotes recovery Save
- Hormone replacement therapy and the risk of asthma attacks: population-based cohort study Save
- Identification and functional assessment of GPCRs across human adipogenesis Save
- Incretin-Based Medications in Women and Reproduction: A Systematic Scoping Review and Consensus Guidelines for Clinical Practice Save
- Metabolomic profiling reveals distinct metabolic signatures in women with functional hypothalamic amenorrhoea (FHA) and polycystic ovary syndrome (PCOS) Save
- Obesity medications versus metabolic bariatric surgery: the debate goes on Save
- Post-bariatric hypoglycaemia: from altered gut physiology to targeted therapies Save
- Prednisolone Once Daily vs Hydrocortisone Thrice Daily in Hypoadrenalism: A Randomized Clinical Trial Save
- Reappraising obesity management in the GLP-1 receptor agonist era Save
- Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation Save