Senthil Kumar Ganesan

About

I am a Principal Scientist at CSIR–IICB, Kolkata, working on the molecular mechanisms of retinal diseases with a focus on epigenetics, metabolic memory, and therapeutic innovation. My lab integrates zebrafish models, CRISPR editing, omics technologies, and nanomedicine to decode retinal remodeling and identify early biomarkers in diabetic retinopathy and retinal cancers. I have extensive expertise in proteomics, metabolomics, and drug delivery systems, with contributions to high-impact publications and translational research. I actively mentor students and welcome collaborations to advance retinal biology into precision therapies.

Employment

• Indian Institute of Chemical Biology CSIR Scientist
  2016 - Present

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (20)

• Unveiling ferroptosis genes and inhibitors in diabetic retinopathy through single-cell analysis and docking simulations
  Biochemistry and Biophysics Reports 2025 DOI: 10.1016/j.bbrep.2025.101932
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• MicroRNA-379-5p attenuates cancer stem cells and reduces cisplatin resistance in ovarian cancer by regulating RAD18/Polη axis
  Cell Death & Disease 2025 DOI: 10.1038/s41419-025-07430-5
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• Tumor-associated macrophages contribute to cisplatin resistance via regulating Pol η-mediated translesion DNA synthesis in ovarian cancer
  Cellular and Molecular Life Sciences 2025 DOI: 10.1007/s00018-025-05731-8
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• The EXO1/Polη/Polι axis as a promising target for miR-3163-mediated attenuation of cancer stem-like cells in non-small cell lung carcinoma
  British Journal of Cancer 2024 DOI: 10.1038/s41416-024-02840-2
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• CD38–RyR2 axis–mediated signaling impedes CD8 + T cell response to anti-PD1 therapy in cancer
  Proceedings of the National Academy of Sciences 2024 DOI: 10.1073/pnas.2315989121
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• Pharmacotherapeutic values of berberine: A Chinese herbal medicine for the human cancer management
  Journal of Biochemical and Molecular Toxicology 2023 DOI: 10.1002/jbt.23278
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• Identification of Epigenetically Modified Hub Genes and Altered Pathways Associated With Retinoblastoma.
  Frontiers in cell and developmental biology 2022 DOI: 10.3389/fcell.2022.743224
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• β-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKβ/NF-κB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats
  Molecules 2021 DOI: 10.3390/molecules26072101
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• The potential role of m6A RNA methylation in diabetic retinopathy.
  Experimental eye research 2021 DOI: 10.1016/j.exer.2021.108616
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• Tumor hypoxia: The major culprit behind cisplatin resistance in cancer patients
  Critical Reviews in Oncology/Hematology 2021 DOI: 10.1016/j.critrevonc.2021.103327
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