0000-0001-6080-3313 About
I am a Postdoctoral Associate in the Acharya Laboratory at Duke University, where I investigate the structural basis of antibody-mediated viral neutralization using cryo-electron microscopy (cryo-EM). My research focuses on understanding how broadly neutralizing antibodies recognize viral glycoproteins, the mechanisms viruses use to evade immune responses, and the structural determinants of antibody resistance. These studies provide insights that support the rational design of next-generation vaccines and antibody-based therapeutics.
I earned my Ph.D. in Structural Immunology from the International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, under the mentorship of Dr. Dinakar Salunke. During my doctoral training, I employed X-ray crystallography and complementary structural biology approaches to investigate antibody-antigen interactions and elucidate the molecular basis of immune recognition.
My research integrates structural biology, virology, and immunology to address challenges posed by emerging and persistent viral pathogens. By combining high-resolution structural techniques with functional and biophysical analyses, I aim to advance our understanding of protective immune responses and contribute to the development of effective vaccines and therapeutic antibodies for diseases of global public health importance.
Employment
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Duke University Postdoctoral Associate
Education
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Duke University PostDoc2024 - Present
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ICGEB PhD2018 - 2023
Projects & Funding
Projects & funding information is unavailable.
Publications (8)
- Mechanistic and antigenic boundaries of Henipavirus and Parahenipavirus glycoproteins Save
- An integrated workflow for structural virology with a 100 keV electron microscope Save
- A novel ER stress regulator ARL6IP5 induces reticulophagy to ameliorate the prion burden Save
- Mechanistic and Antigenic Boundaries of Henipavirus and Parahenipavirus Glycoproteins Save
- Dynamics of lipid displacement inside the hydrophobic cavity of a nonspecific lipid transfer protein from Solanum melongena Save
- A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein Save
- Epitope‐directed anti‐SARS‐CoV‐2 scFv engineered against the key spike protein region could block membrane fusion Save
- α-Glucosidase inhibition activity and in silico study of 2-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one, a synthetic derivative of flavone Save