Clara A MOREAU
Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, University of Paris V, Keck Hospital of USC
Research areas: Biochemistry, Genetics and Molecular Biology · Genetics · Genetics and Neurodevelopmental Disorders · Functional Brain Connectivity Studies · Genomic variations and chromosomal abnormalities
0000-0001-6217-731X
About
Neuroimaging, Psychiatry, and Genomics
Polygenicity and genetic heterogeneity pose great challenges for studying mechanisms - such as brain connectivity - underlying neurodevelopmental psychiatric conditions.
Genetic-first approaches have been implemented in neuroimaging studies to address this issue of heterogeneity. How psychiatric genomic risk with various polygenicity levels impact brain features remains largely unknown.
My work aims to understand the effect on the human brain of neurodevelopmental psychiatric disorders genomic risk factors with various levels of complexity: oligo-, multi-genic copy number variants (CNVs), and polygenic risk scores (PRS) as well as idiopathic psychiatric conditions and traits.
Employment
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CHU Sainte-Justine Researcher2024 - Present
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Université de Montréal Assistant Professor2024 - Present
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Keck Hospital of USC Research associate2023 - 2024
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Institut Pasteur Postdoctoral researcher2021 - 2022
Education
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University of Montreal PhD in Neurosciences2015 - 2020
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University of Paris V Bachelor2009 - 2012
Projects & Funding
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Global fMRI Initiative within the ENIGMA Consortium NIH2026 - 2031
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Comprehensive phenotyping for precision care in anorexia nervosa Centre de recherche Azrieli du CHU Sainte-Justine2026 - 2028
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Impact des restrictions alimentaires sur la maturation cérébrale dans les troubles du neurodéveloppement Fondation de la recherche pédiatrique2026 - 2026
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De l’hétérogénéité clinique à la médecine de précision en psychiatrie: Apport de la neuroimagerie à grande échelle FRQS2026 - 2030
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Multifeature brain investigation of genetic liability for neurodevelopmental and psychiatric disorders Canadian Institutes of Health Research2025 - 2030
Publications (35)
- Categorical and Dimensional Alterations Along Two Principal Cortical Gradient Axes Across the Schizophrenia-Bipolar Spectrum Save
- Lifespan normative modeling of brain microstructure Save
- Brain morphology in Anorexia Nervosa and its subtypes: A multi-cohort study of individual participant data Save
- Copy number variants reveal divergent genetic and diagnostic cortical signatures across psychiatric disorders Save
- Neuroimaging insights into brain mechanisms of early-onset restrictive eating disorders Save
- Cortical differences across psychiatric disorders and associated common and rare genetic variants Save
- High-precision machine learning identifies a reproducible functional connectivity signature of autism spectrum diagnosis in a subset of individuals Save
- Lifespan Normative Modeling of Brain Microstructure Save
- Neuroimaging Insights into Brain Mechanisms of Early-onset Restrictive Eating Disorders Save
- Genetic and phenotypic similarity across major psychiatric disorders: a systematic review and quantitative assessment Save
- Pervasive alterations of intra-axonal volume and network organization in young children with a 16p11.2 deletion Save
- Phenotypic effects of genetic variants associated with autism Save
- Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions Save
- Using rare genetic mutations to revisit structural brain asymmetry Save
- Genetic Heterogeneity Shapes Brain Connectivity in Psychiatry Save
- Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence Save
- Dissecting autism and schizophrenia through neuroimaging genomics Save
- Atlas of functional connectivity relationships across rare and common genetic variants, traits, and psychiatric conditions Save
- 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans Save
- Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia Save