Xiangyi Jiang
Shandong University
Research areas: Medicine · Infectious Diseases · HIV/AIDS drug development and treatment · Computational Drug Discovery Methods · HIV Research and Treatment
0000-0001-6224-2513
About
Xiangyi Jiang, Postdoctoral Fellow at Shandong University. He received his Ph.D. in Medicinal Chemistry from Shandong University in 2025, and then joined the research group of Prof. Xinyong Liu and Prof. Peng Zhan for postdoctoral research. His research focuses on the key challenges of drug resistance and latent infection in AIDS therapy, aiming to develop novel anti-HIV-1 agents with potent anti-drug resistance activity and the ability to eliminate viral latent reservoirs. To date, he has published more than 10 SCI papers as the first author in journals including Journal of Medical Virology, Communications Chemistry, and European Journal of Medicinal Chemistry.
Employment
- 2025 - Present
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (31)
- Molecular glues: Recent advances in cereblon substrate identification and mechanistic insights Save
- Discovery of Potent 1,2,4-Triazole-Derived HIV Capsid Modulators with Dual-Stage Antiviral Activity via Targeting the Unexplored GTNQ Sub-Pocket Using a Multi-Site Binding Strategy Save
- Targeted Degradation of Capsid by Host-Hijacking PROTAC Overcomes Drug Resistance Save
- Discovery of low‐molecular‐weight phenylalanine derivatives as novel HIV capsid modulators with improved antiretroviral activity and metabolic stability Save
- Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors Save
- Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators Save
- Identification of novel 1,2,3-triazole isatin derivatives as potent SARS-CoV-2 3CLpro inhibitors via click-chemistry-based rapid screening Save
- The discovery and design of novel HIV-1 capsid modulators and future perspectives. Save
- The current progress in the use of boron as a platform for novel antiviral drug design. Save
- Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators. Save
- Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators. Save
- Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulators. Save
- Design, Synthesis and Structure-Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction. Save
- Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778. Save
- Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein. Save
- Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors. Save
- Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C. Save
- Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability. Save
- Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors. Save
- Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors. Save