G. Janani
Cornell University, McGowan Institute for Regenerative Medicine, Kumaraguru College of Technology, Indian Institute of Technology Guwahati
0000-0001-6280-5953
About
I am currently working as a Postdoctoral Associate at the Cornell University, Ithaca, USA, where my research focuses on developing mechanoactive aortic valve model, organ-on-chip platforms, and cell-type specific GTPase activity for disease modeling, personalized medicine, and point-of-care diagnostics. My work integrates biomaterials, microfabrication, and biomedical device development to address clinically relevant problems through interdisciplinary research.
My research interests include Tissue Engineering & Regenerative Therapeutics; Cardiovascular engineering; Calcific aortic valve disease; Bioartificial liver; GTPase signaling; Mechanobiology; Immunoengineering; Therapeutic Biomarker Discovery & Validation; Multi-organ disease models; Molecular and Cellular Engineering; Gene Delivery Technologies; Matrix-bound nanovesicles; Host tissue-biomaterial interface; Macrophage polarization; Immunomodulation; AI-based image analysis.
My long-term research vision is to establish a multidisciplinary laboratory focused on next-generation microphysiological systems, organ-on-chip technologies, and precision diagnostic platforms. I aim to develop clinically relevant in vitro models that improve our understanding of human diseases while reducing dependence on animal models. I also envision translating laboratory innovations into affordable healthcare technologies suitable for resource-limited settings, aligning with India's growing emphasis on indigenous biomedical innovation and translational research.
Employment
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Cornell University Postdoctoral Associate2023 - Present
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McGowan Institute for Regenerative Medicine Fulbright Research Fellow2018 - 2019
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Indian Institute of Technology Guwahati Junior Research Fellow2015 - 2016
Education
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Kumaraguru College of Technology B.Tech Biotechnology2009 - 2013
Projects & Funding
Projects & funding information is unavailable.
Publications (22)
- Unidirectional Shear Stress–Operated NOTCH/CXCR4 Molecular Switch Controls Semilunar Valve Maturation and Collagen Stratification Save
- Active endothelial and neural regulation of valve biology, health, and disease Save
- Valve endothelial monolayer fissuring and interstitial matrix fracture triggers calcific lesion formation via GTPase signaling Save
- Valve endothelial monolayer fissuring via RhoA activity induces 3D calcific aortic valve lesion emergence as revealed by a longitudinal live-imaging platform Save
- Cell-type Specific GTPase Regulation of Aortic Valve Homeostasis and CAVD Progression Save
- Microfluidic human physiomimetic liver model as a screening platform for drug induced liver injury Save
- Silk fibroin bioscaffold from Bombyx mori and Antheraea assamensis elicits a distinct host response and macrophage activation paradigm in vivo and in vitro Save
- Mimicking Native Liver Lobule Microarchitecture In Vitro with Parenchymal and Non-parenchymal Cells Using 3D Bioprinting for Drug Toxicity and Drug Screening Applications Save
- Silk Fibroin Based Formulations as Potential Hemostatic Agents Save
- Surface Modification of Decellularized Natural Cellulose Scaffolds with Organosilanes for Bone Tissue Regeneration Save