Maria Thomas

About

I have studied Biochemistry emphasized on Molecular Biology in Moscow. Since 2009 I work at the Institute of Clinical Pharmacology in Stuttgart with focus on the regulation of drug-metabolizing enzymes by nuclear receptors in primary human hepatocytes.
Currently we are part of the Virtual Liver Network consortium, where we are concentrating on defining the functions that take place within cells in the liver. Using this information we try to develop computational models representing them.

Employment

• Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
  2009 - Present
• Natural and Medical Institute
  2007 - 2008

Education

• University of Tuebingen PhD
  2003 - 2006
• Lomonosov Moscow State University Diplom
  1994 - 1999

Projects & Funding

Projects & funding information is unavailable.

Publications (53)

• Coordinating Role of RXRalpha in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling
  PLoS computational biology 2016 DOI: 10.1371/journal.pcbi.1004431
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• A Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells
  Drug Metabolism and Disposition 2015 DOI: 10.1124/dmd.114.060962
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• Activating and Inhibitory Functions of WNT/beta-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells
  Molecular Pharmacology 2015 DOI: 10.1124/mol.114.097402
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• Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists
  Drug metabolism and disposition: the biological fate of chemicals 2015 DOI: 10.1124/dmd.115.064667
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• Hepatocyte fate upon TGF-beta challenge is determined by the matrix environment
  Differentiation 2015 DOI: 10.1016/j.diff.2015.04.001
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• LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods
  Plos One 2015 DOI: 10.1371/journal.pone.0135852
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• Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2
  Cellular Signalling 2015 DOI: 10.1016/j.cellsig.2014.12.016
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• Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice
  Bmc Systems Biology 2015 DOI: 10.1186/s12918-015-0229-0
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• Peroxisome proliferator-activated receptor alpha, PPAR alpha, directly regulates transcription of cytochrome P450 CYP2C8
  Frontiers in Pharmacology 2015 DOI: 10.3389/fphar.2015.00261
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• Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained
  Epigenetics & Chromatin 2015 DOI: 10.1186/s13072-015-0002-z
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