Takshashila Tripathi, Ph.D.

About

I am involved in teaching various modules in the Department of Neuroscience, Physiology & Pharmacology and Department of Cell & Developmental Biology at University College London.
I finished my Ph.D. in 2015 from 'School of Molecular and Regenerative Medicine' in Italy and later in my first post-doc I worked on neurodevelopmental and neurodegenerative diseases such as Autism and Huntington’s disease. In my second post-doc I worked on Alzheimer’s disease in Prof. Frances Edwards Lab at University College London.

Employment

• University College London Lecturer (Teaching)
  2021 - 2024
• University College London Postdoctoral Research Fellow
  2019 - 2023
• University of Trento Postdoctoral fellow, NeuroEpigenetics Laboratory https://biagiolilab.wordpress.com/
  2015 - 2018

Education

• Aligarh Muslim University Masters in (Ag.) Microbiology
• University of Delhi B.Sc. in Microbiology (Hons.)

Projects & Funding

Projects & funding information is unavailable.

Publications (25)

• Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer’s disease without mutations inMAPT
  2024 DOI: 10.1101/2024.11.04.621900
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• CircHTT(2,3,4,5,6) — co-evolving with the HTT CAG-repeat tract — modulates Huntington's disease phenotypes
  Molecular Therapy - Nucleic Acids 2024 DOI: 10.1016/j.omtn.2024.102234
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• Multifunctional Nanocarriers for Alzheimer’s Disease: Befriending the Barriers
  Mohammad Azam Ansari, Takshashila Tripathi, Baskar Venkidasamy +10 more
  Molecular Neurobiology 2023 DOI: 10.1007/s12035-023-03730-z
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• CAG repeat expansion in the Huntington’s disease gene shapes linear and circular RNAs biogenesis
  PLOS Genetics 2023 DOI: 10.1371/journal.pgen.1010988
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• CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing
  Nucleic Acids Research 2022 DOI: 10.1093/nar/gkac1134
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• Polyphenols and Their Nanoformulations: Protective Effects against Human Diseases
  Santosh Anand, Sowbhagya Ramachandregowda, Mohammad Azam Ansari +6 more
  Life 2022 DOI: 10.3390/life12101639
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• A07 Circ HTT, a novel circular rna molecule from the huntington’s disease gene locus: functional characterization and pathophysiological implications
  A: Pathogenic mechanisms 2022 DOI: 10.1136/jnnp-2022-ehdn.7
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• D12 Faulty linear and back-splicing in Huntington’s disease: novel players in the pathologic process hint at innovative RNA biomarkers
  D: Wet biomarkers 2022 DOI: 10.1136/jnnp-2022-ehdn.68
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• Upregulation of Trem2 expression occurs exclusively on microglial contact with plaques
  2022 DOI: 10.1101/2022.01.26.477873
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• Mechanisms of stress adaptation by bacterial communities
  Saurabh Pandey, Raunak, Takshashila Tripathi +3 more
  Microbial Syntrophy-mediated Eco-enterprising 2022 DOI: 10.1016/B978-0-323-99900-7.00013-4
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• Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology
  Cell Reports 2022 DOI: 10.1016/j.celrep.2022.111686
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• Defective linear and circular RNAs biogenesis in Huntington’s disease: CAG repeat expansion hijacks neuronal splicing
  [] 2021 DOI: 10.1101/2021.12.27.474266
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• Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia
  Molecular Neurodegeneration 2021 DOI: 10.1186/s13024-021-00457-0
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• Role of Microbial Nanotechnology in Diagnostics
  Sidak Minocha, Priya Khadgawat, Arunima Bhattacharjee +4 more
  Microbial Nanotechnology: Green Synthesis and Applications 2021 DOI: 10.1007/978-981-16-1923-6_12
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• A04 Circhtt, a circular rna from the huntington’s disease gene locus: functional characterization and possible implications for disease modulation
  A: Pathogenic mechanisms 2021 DOI: 10.1136/jnnp-2021-ehdn.4
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• Lessons from SARS-CoV-2 Pandemic: Evolution, Disease Dynamics and Future
  Saurabh Pandey, Bharat Yadav, Arvind Pandey +4 more
  Biology 2020 DOI: 10.3390/biology9060141
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• CHD8 Suppression Impacts on Histone H3 Lysine 36 Trimethylation and Alters RNA Alternative Splicing.
  CHD8 Suppression Impacts on Histone H3 Lysine 36 Trimethylation and Alters RNA Alternative Splicing. 2020 DOI: 10.1101/2020.03.14.992032
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• Bacterial metabolic fitness during pathogenesis
  Saurabh Pandey, Nidhi Shukla, Shashi Shekhar Singh +3 more
  Microbial Versatility in Varied Environments: Microbes in Sensitive Environments 2020 DOI: 10.1007/978-981-15-3028-9_12
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• TAT-peptide conjugated repurposing drug against SARS-CoV-2 main protease (3CLpro): Potential therapeutic intervention to combat COVID-19
  Arabian Journal of Chemistry 2020 DOI: 10.1016/J.ARABJC.2020.09.037
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• Hypomorphic mutation of the mouse Huntington's disease gene orthologue.
  PLoS genetics 2019 DOI: 10.1371/journal.pgen.1007765
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