Manisha Yadav

Employment

• University of Toronto PhD Student
  2020 - Present

Education

• University of Toronto PhD
  2020 - 2026
• University of Saskatchewan Master of Science
  2017 - 2020

Projects & Funding

Projects & funding information is unavailable.

Publications (9)

• High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin
  Proceedings of the National Academy of Sciences 2026 DOI: 10.1073/pnas.2520462123
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• PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites
  Nucleic Acids Research 2025 DOI: 10.1093/nar/gkaf347
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• A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins.
  Journal of medicinal chemistry 2024 DOI: 10.1021/acs.jmedchem.4c02010
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• Huntingtin is an RNA binding protein and participates in NEAT1 -mediated paraspeckles
  Science Advances 2024 DOI: 10.1126/sciadv.ado5264
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• DDX41 is required for cGAS-STING activation against DNA virus infection
  Cell Reports 2022
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• Structure-function analysis of DEAD-box helicase DDX43
  Methods 2022
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• The KH domain facilitates the substrate specificity and unwinding processivity of DDX43 helicase
  The Journal of Biological Chemistry 2020
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• Structure and Function of KH Domain in DDX43 and DDX53 Cancer Antigen Helicases
  2020
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• Biochemical characterization of INTS3 and C9ORF80, two subunits of hNABP1/2 heterotrimeric complex in nucleic acid binding
  Biochemical Journal 2018
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