MH
Michael Vaclav Holmes
23andMe (United States), University of Oxford, University College London, London School of Hygiene & Tropical Medicine, University of Pennsylvania
Research areas: Biochemistry, Genetics and Molecular Biology · Genetics · Genetic Associations and Epidemiology · Lipoproteins and Cardiovascular Health · Genetic Mapping and Diversity in Plants and Animals
0000-0001-6617-0879
Employment
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23andMe (United States) Principal Scientist2022 - Present
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University of Oxford Associate Professor2014 - 2022
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University of Pennsylvania Assistant Professor2013 - 2014
Education
- 2009 - 2014
- 2009 - 2010
- 2002 - 2005
Projects & Funding
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Drug target validation and risk prediction for coronary heart disease using targeted blood-based metabolomics and proteomics British Heart Foundation2018 - Present
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Assessing health risks associated with exposure to household and ambient air pollution in rural and urban China Medical Research Council2017 - 2019
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Public health applications of cardiovascular genomics Medical Research Council2009 - 2013
Publications (64)
- Polygenic prediction of treatment response for precision medicine is vulnerable to collider bias Save
- Analysis of 3.6 million individuals yields minimal evidence of pairwise genetic interactions for height Save
- Evaluating genetically-predicted causal effects of lipoprotein(a) in human diseases: a phenome-wide Mendelian randomization study Save
- Trans-ancestral Genome Wide Association Study of Sporadic and Recurrent Miscarriage Save
- Prospective analysis of incident disease among individuals of diverse ancestries using genetic and conventional risk factors Save
- Guidelines for performing Mendelian randomization investigations: update for summer 2023 Save
- Systematic disease-agnostic identification of therapeutically actionable targets using the genetics of human plasma proteins Save
- A genome-wide association study of childhood adiposity and blood lipids [version 2; peer review: 2 approved, 3 approved with reservations] Save
- Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysis Save
- Constructing an atlas of associations between polygenic scores from across the human phenome and circulating metabolic biomarkers Save
- A phenome-wide bidirectional Mendelian randomization analysis of atrial fibrillation Save
- Visceral adiposity is associated with metabolic profiles predictive of type 2 diabetes and myocardial infarction Save
- Chronic pain is associated with higher risk of developing and being hospitalized for COVID-19: a Mendelian randomization study Save
- Associations between body composition, fat distribution and metabolic consequences of excess adiposity with severe COVID-19 outcomes: observational study and Mendelian randomisation analysis Save
- Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study Save
- The relationship between BMI and COVID-19: exploring misclassification and selection bias in a two-sample Mendelian randomisation study Save
- Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation Save
- Mendelian randomization Save
- Obesity and risk of female reproductive conditions: A Mendelian randomisation study Save
- A genome-wide association study of childhood adiposity and blood lipids Save