0000-0001-6774-3149 About
Steven’s work combines epidemiological study design, statistical modelling, and computational biology, including genetic and other multi-omic analyses, to generate evidence that can support clinical and public health decisions, with a particular interest in translation to personalised (precision) medicine. He has experience using large-scale population and healthcare datasets and translating complex analyses into interpretable, decision-relevant insights.
He is based in the ECHO (Epidemiology of Cancer Healthcare & Outcomes) research group at UCL working on projects with specific aims in earlier and more effective cancer diagnosis and care, including:
- Diagnostic intervals and pathways: investigating potentially avoidable delays in the diagnosis of symptomatic patients with underlying (as-yet-undiagnosed) cancer, and the mechanisms responsible for these delays.
- Prodromal symptoms of cancer: quantifying the predictive value of presenting symptoms and tests for cancer (and other consequential illness) among patients consulting in primary care.
- Variation in cancer health care: analysing differences in cancer diagnosis and treatment between patients and healthcare organisations, in England and other countries, to target interventions that reduce unwarranted variation.
More widely, Steven is interested in individual participant data meta-analysis (IPD-MA), the use of electronic health records (EHR) for medical research, and the application and integration of “-omic” technologies (for example metabolomics, proteomics, phenomics, and transcriptomics). His genomic work includes genome-wide association studies (GWAS), analyses of whole-genome data (germline and somatic), and risk stratification approaches such as polygenic risk scores (PRS). He also works with machine learning approaches and longitudinal modelling to understand change over time and heterogeneity in risk and outcomes.
He has published across general medicine, epidemiology, and disease-focused journals, and contributes to the research community through editorial roles, committee membership, training leadership, mentorship, and equality, diversity and inclusion (EDI) work.
Employment
Employment history is unavailable.
Education
Education history is unavailable.
Projects & Funding
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Using Multi-Modal Data Integration Across Breast Cancer Molecular Subtypes to Develop Predictors of Treatment Response, Early Relapse, and Survival and to Explore Early Signals of Later Metastatic Recurrence Congressionally Directed Medical Research Programs2023 - 2027
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Using genetics to better understand disease processes in cerebral small vessel disease and vascular cognitive impairment to improve treatment and prediction British Heart Foundation2022 - 2026
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Alcohol Harms: The relationship between alcohol consumption and cardiovascular risk - A life-course perspective Medical Research Council2015 - 2018
Publications (107)
- Alcohol Intake and Health Study: No Protective Effect at Low Levels, With Mortality Increasing to 1 in 25 at 14 Drinks Per Week Save
- Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts Save
- Evaluating progesterone receptor agonist megestrol plus letrozole for women with early-stage estrogen-receptor-positive breast cancer: the window-of-opportunity, randomized, phase 2b, PIONEER trial Save
- Navigating the shifting Mendelian randomisation landscape: some observations and suggestions for editors, reviewers and investigators Save
- Address academic bullying through structural reform Save
- Steatotic liver disease is a marker of multimorbidity, not underlying cirrhosis, in older adults Save
- Health characteristics and health behaviours in male former contact sports participants: comparison with general population controls in a Finnish cohort study Save
- Novel loci and biomedical consequences of iron homoeostasis variation Save
- Large-scale analysis of whole genome sequencing data from formalin-fixed paraffin-embedded cancer specimens demonstrates preservation of clinical utility Save
- Do iron homeostasis biomarkers mediate the associations of liability to type 2 diabetes and glycemic traits in liver steatosis and cirrhosis: a two-step Mendelian randomization study Save
- Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction Save
- Nucleus of fairness: epigenetic ageing, social determinants of health and the imperative for proactive preventive measures Save
- Apathy After Stroke Incidence, Symptom Trajectory, and Impact on Quality of Life and Disability Save
- Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease Save
- A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases Save
- Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation Save
- Development and validation of a nomogram for predicting internal mammary sentinel node metastasis in breast cancer patients Save
- The write algorithm: promoting responsible artificial intelligence usage and accountability in academic writing Save
- A comprehensive evaluation of the longitudinal association between alcohol consumption and a measure of inflammation: Multiverse and vibration of effects analyses Save
- Association of gout with brain reserve and vulnerability to neurodegenerative disease Save