Roshani Sinha

Employment

Employment history is unavailable.

Education

• Universitat Pompeu Fabra PhD in Biomedicine
  2012 - 2017
• Kingston University Master of Science in Cancer Biology
  2010 - 2012
• Sri Indu College of Engineering & Technology Bachelor of Technology in Biotechnology
  2006 - 2010

Projects & Funding

Projects & funding information is unavailable.

Publications (15)

• Novel humanized loss-of-function NF1 mouse model of juvenile myelomonocytic leukemia
  Roshani Sinha, Rachana Vinay Patil, Rosa Romano +10 more
  Blood Advances 2026 DOI: 10.1182/bloodadvances.2024015191
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• Lentiviral vectors for hematopoietic stem cell gene therapy restore α-globin expression in α-thalassemia red blood cells
  Cell Reports Medicine 2025 DOI: 10.1016/j.xcrm.2025.102362
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• Protocol for efficient CRISPR/AAV-mediated genome editing and erythroid differentiation of human hematopoietic stem and progenitor cells
  STAR Protocols 2025 DOI: 10.1016/j.xpro.2025.104018
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• Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis
  Aadit P. Shah, Kiran R. Majeti, Freja K. Ekman +13 more
  Nature Communications 2025 DOI: 10.1038/s41467-025-56239-5
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• Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells
  Simon N. Chu, Eric Soupène, Devesh Sharma +22 more
  Cell Reports 2025 DOI: 10.1016/j.celrep.2024.115141
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• Engineering inducible signaling receptors to enable erythropoietin-free erythropoiesis
  Aadit P. Shah, Kiran R. Majeti, Freja K. Ekman

  +13 more

  • Sridhar Selvaraj
  • Eric Soupène
  • Prathamesh Chati
  • Roshani Sinha
  • Sofia E. Luna
  • +8 more
  2024 DOI: 10.1101/2024.04.12.589260
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• Epigenetic Profiling of PTPN11 Mutant JMML Hematopoietic Stem and Progenitor Cells Reveals an Aberrant Histone Landscape
  Roshani Sinha, Mai Dvorak, Ananthakrishnan Ganesan +13 more
  Cancers 2023 DOI: 10.3390/cancers15215204
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• Epigenetic Profiling of PTPN11 Mutant JMML Hematopoietic Stem and Progenitor Cells Reveals an Aberrant Histone Landscape
  2023 DOI: 10.20944/preprints202310.0385.v1
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• G-CSF +/- Plerixafor PBSC Mobilization and αβ t-Cell/CD19 B-Cell Depletion Impact Donor T-Cell Gene Expression Profiles
  Transplantation and Cellular Therapy 2023 DOI: 10.1016/s2666-6367(23)00370-6
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• Novel Humanized Loss-of-Function NF1 Mouse Model of Juvenile Myelomonocytic Leukemia
  Roshani Sinha, Rachana Vinay Patil, Rosa Romano +5 more
  Blood 2022 DOI: 10.1182/blood-2022-167413
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• Kinetics of Gamma Delta T-Cell Immune Reconstitution: An Immunophenotypic and Molecular Analysis
  Transplantation and Cellular Therapy 2022 DOI: 10.1016/s2666-6367(22)00614-5
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• Aberrant Histone Landscape in Juvenile Myelomonocytic Leukemia
  Roshani Sinha, Mai Dvorak, Charlotte Marie Niemeyer +6 more
  Blood 2021 DOI: 10.1182/blood-2021-152074
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• Development of embryonic and adult leukemia mouse models driven by MLL-ENL translocation
  Experimental Hematology 2020 DOI: 10.1016/j.exphem.2020.04.008
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• Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation
  The EMBO Journal 2020 DOI: 10.15252/embj.2019104270
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• γδ T cells: a potent immunotherapy tool for children with high-risk acute leukemia
  Cytotherapy 2019 DOI: 10.1016/j.jcyt.2019.03.349
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