Pham Thanh Duy; Duy Pham Thanh; Duy Thanh Pham; Duy PT, PT Duy; Duy Pham; Pham T Duy; Duy T Pham
Oxford University Clinical Research Unit
Research areas: Medicine · Microbiology · Salmonella and Campylobacter epidemiology · Antibiotic Resistance in Bacteria · Antibiotic Use and Resistance
0000-0001-7029-9210
About
I lead the Molecular Epidemiology group at Oxford University Clinical Research Unit (OUCRU) in Vietnam. My group investigates molecular evolution, genomic epidemiology, and clinical impact of drug-resistant bacterial infections in Vietnam and across Asia. Our research is multidisciplinary—combining genomics, molecular biology, epidemiology, and clinical data to elucidate the factors shaping the evolution and transmission of antimicrobial-resistant (AMR) pathogens and their clinical consequences. My long-term vision is to tackle local and regional public health challenges driven by drug-resistant bacteria through locally led, high-quality research.
Since 2008, I have conducted research on typhoid fever (Salmonella Typhi and Paratyphi A) and diarrheal diseases (diarrheagenic E. coli, Shigella, and non-typhoidal Salmonella). More recently, my work has expanded to include community-acquired bloodstream infections (ExPEC and Klebsiella pneumoniae) and hospital-acquired infections (A. baumannii and K. pneumoniae).
My ongoing projects are multidisciplinary and employ cutting-edge approaches. A key Wellcome-funded project investigates the emergence and impact of azithromycin-resistant typhoid fever in South Asia, integrating genomics, transcriptomics, macrophage assays, and evolutionary experiments within a clinical trial framework. Additional projects examine the impact of antibiotic therapy on the human gut microbiome, horizontal plasmid transfer, and the evolution of AMR in children with typhoid fever and dysentery.
My current focus is the genomic epidemiology, ecological dynamics, and evolutionary patterns of hypervirulence and antimicrobial resistance in Klebsiella pneumoniae. In collaboration with the University of Oxford, I am characterizing adaptive immune responses to K. pneumoniae protein candidates in patients with bloodstream infections. I also lead a multi-country Klebsiella pneumoniae genomic surveillance network across Wellcome-funded Major International Programmes in Vietnam, Cambodia, Indonesia, Kenya, Malawi, and South Africa.
Employment
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Oxford University Clinical Research Unit Head of Molecular Epidemiology
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (100)
- Determining intracellular and extracellular activities of azithromycin against azithromycin-resistant Salmonella Typhi and their association with clinical treatment responses Save
- Azithromycin with or without cefixime for suspected or culture-confirmed uncomplicated typhoid fever in Nepal, Bangladesh, and Pakistan (ACT-South Asia): a double-blind, parallel-group, randomised, placebo-controlled, phase 4 trial Save
- Efficacy and Safety of Newer Antibiotics Versus Generic Antibiotics for Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia: A Systematic Review and Meta-analysis of Randomized Controlled Trials Save
- Cross- Wellcome Africa Asian Programmes (AAPs) Acceleration of Genomics for Escalating infectious Diseases, (CAGED) Consortium Save
- Predominance of NDM and OXA‐48 Carbapenemase Coharboring Among Carbapenem Nonsusceptible Enterobacterales Isolates From Clinical Specimens at a Tertiary Hospital in Vietnam Save
- Secondary infection in severe COVID-19 patients: clinical and microbial patterns at a tertiary hospital in Vietnam Save
- Differential gut transmission of IncP plasmid clades involving hypervirulent Klebsiella pneumoniae reveals plasmid-specific ecological adaptation Save
- The bacterial etiology and antimicrobial susceptibility of lower respiratory tract infections in Vietnam. Save
- Changing epidemiology and antimicrobial susceptibility of bloodstream infections at a Vietnamese infectious diseases hospital (2010–2020) Save
- The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi Save
- Understanding maternal sepsis risk factors and bacterial etiology: A case control study protocol. Save
- A retrospective investigation of the population structure and geospatial distribution of Salmonella Paratyphi A in Kathmandu, Nepal Save
- Genomic insights unveil the plasmid transfer mechanism and epidemiology of hypervirulent Klebsiella pneumoniae in Vietnam Save
- Genomic characterization of Aeromonas spp. isolates from striped catfish with motile Aeromonas septicemia and human bloodstream infections in Vietnam. Save
- The impact of antibiotics on the gut microbiota of children recovering from watery diarrhoea Save
- Development and validation of multiplex real-time PCR for simultaneous detection of six bacterial pathogens causing lower respiratory tract infections and antimicrobial resistance genes Save
- Multidrug resistance plasmids underlie clonal expansions and international spread of Salmonella enterica serotype 1,4,[5],12:i:- ST34 in Southeast Asia Save
- Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes Save
- Prevalence and Associated Factors of optrA-Positive-Enterococcus faecalis in Different Reservoirs around Farms in Vietnam Save
- The clinical features and genomic epidemiology of carbapenem-resistant Acinetobacter baumannii infections at a tertiary hospital in Vietnam. Save