Quaiser Saquib
King Saud University, Aligarh Muslim University
Research areas: Materials Science · Materials Chemistry · Nanoparticles: synthesis and applications · Carcinogens and Genotoxicity Assessment · Pesticide Exposure and Toxicity
0000-0001-7030-3777
About
Dr. Saquib received Ph.D. from the Department of Ag. Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, India in 2009. Lately, he joined at Department of Zoology, in King Saud University. Much of his experience has been doing the DNA damage and molecular toxicity assessment of nanoparticles, pesticides and anti-cancer drugs in human lymphocytes, cell lines and animals models. He have ample experience in working with sophisticated instruments and molecular biology assays employed for toxicity assessment including flow cytometric analysis of cell cycle, apoptosis, Ca2+ influx, level of intracellular glutathione, free radicals analysis (including nitric oxide), and dissipation of mitochondrial membrane potential, respectively. Using the comet and cytokinesis blocked micronucleus assays He can quantify DNA damage and chromosomal breaks in the above mentioned test models. With his immunofluorescence skills, visualization of expression of apoptosis and cell death related proteins in cell lines can be done. Also he gained experience in qPCR array to quantitate the expression of 84 genes responsible for human toxicity and oxidative stress. Since, many features of programmed cell death in plants resemble with those observed in animals, in this regard, very recently, he got success in deciphering the mechanism of cell death in plant test system upon exposure with different nanoparticles. In addition to the basic and molecular biology techniques, he has good experience in bio-physical interaction analysis of biological macromolecules, which includes the interaction mechanism of binding of exogenous ligands with DNA and human serum albumin employing the spectrofluorescence measurements, cyclic voltammetry and circular dichroism. He earned the Environmental Mutagen Society of India (EMSI-2008) Young Scientist Award for the outstanding contribution in molecular toxicology research. Dr. Saquib is also serving as Co-Investigator in two projects funded by National Plan for Science and Technology, Saudi Arabia. Besides his deep involvement in research, he works as a resource person in training programs for postgraduate students and researchers in molecular techniques. Also, he is engaged in teaching the undergraduate students at Zoology Department, KSU.
Employment
Education
- 2003 - 2009
Projects & Funding
Projects & funding information is unavailable.
Publications (104)
- Copper–Iron Oxide Nanoparticles Induce Apoptosis and Cell Cycle Arrest in Human Airway Epithelial Cells via Oxidative Stress and ROS Generation Save
- Identification of Phytochemicals from Arabian Peninsula Medicinal Plants as Strong Binders to SARS-CoV-2 Proteases (3CLPro and PLPro) by Molecular Docking and Dynamic Simulation Studies Save
- Covalent Inhibitors from Saudi Medicinal Plants Target RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2 Save
- Marine Natural Compound (Neviotin A) Displays Anticancer Efficacy by Triggering Transcriptomic Alterations and Cell Death in MCF-7 Cells Save
- Effectiveness of Nonfunctionalized Graphene Oxide Nanolayers as Nanomedicine against Colon, Cervical, and Breast Cancer Cells Save
- Tris(2-butoxyethyl) phosphate (TBEP): A flame retardant in solid waste display hepatotoxic and carcinogenic risks for humans Save
- Cyto-Genotoxic and Transcriptomic Alterations in Human Liver Cells by Tris (2-Ethylhexyl) Phosphate (TEHP): A Putative Hepatocarcinogen Save
- Organophosphorus Flame Retardant TDCPP Displays Genotoxic and Carcinogenic Risks in Human Liver Cells Save
- Aloe vera-induced apoptotic cell death through ROS generation, cell cycle arrest, and DNA damage in human breast cancer cells Save
- Green synthesis of silver nanoparticles using Phoenix dactylifera seed extract and its anticancer effect against human lung adenocarcinoma cells Save
- Neodymium oxide nanostructures and their cytotoxic evaluation in human cancer cells Save
- Strontium-Doped Nickel Oxide Nanoparticles: Synthesis, Characterization, and Cytotoxicity Study in Human Lung Cancer A549 Cells Save
- Marine Macroalgae Display Bioreductant Efficacy for Fabricating Metallic Nanoparticles: Intra/Extracellular Mechanism and Potential Biomedical Applications Save
- SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection Save
- Carbofuran cytotoxicity, DNA damage, oxidative stress, and cell death in human umbilical vein endothelial cells: Evidence of vascular toxicity Save
- Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells Save
- Organophosphorus flame‐retardant tris(1‐chloro‐2‐propyl)phosphate is genotoxic and apoptotic inducer in human umbilical vein endothelial cells Save
- Protective effects of Nigella sativa extract against H2O2‐induced cell death through the inhibition of DNA damage and cell cycle arrest in human umbilical vein endothelial cells (HUVECs) Save
- Cytotoxic and molecular assessment against breast (MCF-7) cancer cells with cobalt oxide nanoballs Save
- Cytotoxic assessment of liver cancer cells (HepG2) with raw, functionalized multiwalled carbon nanotubes and their comparison with nanohydroxyapatite Save