DHARMENDRA KUMAR KHATRI
National Institute of Pharmaceutical Education and Research, Padmashree Dr D Y Patil Institute of Pharmaceutical Sciences and Research, Institute of Chemical Technology
0000-0001-7066-7706
About
Neuroscience: MicroRNAs: Theranostic: Parkinson's Disease: Nose to brain delivery
We are trying to understand the α-synuclein dysregulation at post-transcriptional (miRNA’s) and post-translational levels (Phosphorylation), leading to its overexpression and transition to toxic oligomeric form in PD. A multidisciplinary approach is employed to investigate the cellular and molecular mechanism underlying the pathogenic degeneration of specific neuronal populations in the brain. In addition, the pharmacological screening of novel molecules isolated from plant sources or synthetic congeners, and targeted drug delivery systems for their neuroprotective and neuronal regeneration properties carried out using cellular and animal models.
Employment
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National Institute of Pharmaceutical Education and Research Assistant Professor2019 - Present
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Padmashree Dr D Y Patil Institute of Pharmaceutical Sciences and Research Assistant Professor2017 - 2019
Education
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Institute of Chemical Technology PhD (TECHNOLOGY)-PHARMACOLOGY2012 - 2017
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Institute of Chemical Technology MASTER OF PHARMACY2010 - 2012
Projects & Funding
Projects & funding information is unavailable.
Publications (156)
- Gut microbiome immune interactions drive neuroinflammation and neurodegeneration in Parkinson’s disease Save
- Natural and Biological Products Therapeutic Potential in Restoring Gut Microbiome: Mechanistic Insights and Clinical Implications Save
- Emerging innovations in ophthalmic drug delivery for diabetic retinopathy: a translational perspective Save
- Acute and subacute dermal toxicity analysis of film forming topical spray of meloxicam: in vitro and in vivo studies Save
- Nrf2–Keap1 Pathway and NLRP3 Inflammasome in Parkinson’s Disease: Mechanistic Crosstalk and Therapeutic Implications Save
- Neuroinflammatory Response and Ubiquitin-Proteasome System Save
- Understanding the influence of TLR-mediated immune system on necroptosis-induced neurodegeneration in Parkinson’s disease Save
- Cell-penetrating proteins and peptides as a promising theragnostic agent for neurodegenerative disorder Save
- Treadmill exercise mitigates rotenone-induced neuroinflammation and α-synuclein level in a mouse model of Parkinson’s disease Save
- Docetaxel and Niclosamide-loaded Nanofiber systems for Improved Chemo-therapeutic Activity and Resistance Reversal in Prostate Cancer Save