Sonia Kumari
Audree Infotech Pvt. Ltd., Parexel, NIPER Mohali, St. Soldier Group of Institution Jalandhar
0000-0001-7187-1768
About
I am currently pursuing my Ph.D. at NIPER Mohali, where my research focuses on applying Computer-Aided Drug Design (CADD) tools for rational therapeutic development. I have extensive experience with drug discovery platforms such as Maestro, MOE, AutoDock, AMBER, and GROMACS, which I use for the design and analysis of small molecules and macromolecules, including peptides and foldamers, while addressing key issues related to toxicity, selectivity, and stability. My work also explores targeted protein degradation strategies, including the design of PROTACs and molecular glues, as well as the identification of novel E3 ligases to expand the range of degradable targets. In addition, I am deeply interested in integrating machine learning and deep learning techniques into drug discovery, particularly through the use of generative AI for small-molecule design and automation tools to enhance workflow efficiency and accelerate discovery.
Employment
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Audree Infotech Pvt. Ltd. Software Engineer2020 - 2021
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Parexel Drug Safety Assistant2020 - 2020
Education
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NIPER Mohali PhD Scholar2021 - 2026
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NIPER Mohali M. Phama2018 - 2020
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St. Soldier Group of Institution Jalandhar Bachelor of Pharmacy (B.Pharm.)2014 - 2018
Projects & Funding
Projects & funding information is unavailable.
Publications (12)
- Beyond CRBN and VHL: Parkin driven lysine-based ternary complexes for selective β3-Tubulin degradation Save
- Impact of IDH Mutations on Ligand Unbinding: Insights from Steered Molecular Dynamics Save
- Leveraging Tubulin Isotype Structural Differences to Design Less Hematotoxic β5 Selective Covalent Inhibitors for NSCLC Save
- An in silico study of protein-protein interactions and design of novel peptides for TrkA in ameloblastoma Save
- Rational design of FXR agonists: a computational approach for NASH therapy Save
- Indole-3 Carbinol and Diindolylmethane Mitigated β-Amyloid-Induced Neurotoxicity and Acetylcholinesterase Enzyme Activity: In Silico, In Vitro, and Network Pharmacology Study Save
- Targeting an Old Foe for Cancer: A Molecular Dynamics Perspective to Unravel the Specific Binding Nature of 2-Methoxy Estradiol to Human β-Tubulin Isotypes Save
- De novo design of potential peptide analogs against the main protease of Omicron variant using in silico studies Save
- Emerging Therapies and Therapeutic Targets for Composite Liver Disease: NASH Save
- Bifunctional robots inducing targeted protein degradation Save