Karthika Natarajan

Employment

• United States Food and Drug Administration Pharmacokineticist
  2024 - Present
• United States Food and Drug Administration Staff Fellow
  2021 - 2024

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (18)

• Particle size affects pharmacokinetics of milled oxycodone hydrochloride tablet products following nasal insufflation in nondependent, recreational opioid users.
  Clinical and translational science 2021 DOI: 10.1111/cts.13053
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• Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation
  Clinical Cancer Research 2018 DOI: 10.1158/1078-0432.ccr-17-1629
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• Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress
  Oncotarget 2016 DOI: 10.18632/oncotarget.10209
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• Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1
  Journal of Visualized Experiments 2016 DOI: 10.3791/53827
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• Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Resistance Proteins ABCB1 and ABCG2
  Pharmaceuticals 2016 DOI: 10.3390/ph9010004
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• The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations
  Investigational New Drugs 2015 DOI: 10.1007/s10637-015-0205-y
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• Functional cyclic AMP response element in the breast cancer resistance protein (BCRP/ABCG2) promoter modulates epidermal growth factor receptor pathway- or androgen withdrawal-mediated BCRP/ABCG2 transcription in human cancer cells
  Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2015 DOI: 10.1016/j.bbagrm.2015.01.003
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• Role of Breast Cancer Resistance Protein (BCRP, ABCG2) in Cancer Outcomes and Drug Resistance
  Resistance to Targeted ABC Transporters in Cancer 2014 DOI: 10.1007/978-3-319-09801-2_3
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• Bcrp1 transcription in mouse testis is controlled by a promoter upstream of a novel first exon (E1U) regulated by steroidogenic factor-1
  2013 DOI: 10.1016/j.bbagrm.2013.10.008
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• The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms
  2013 DOI: 10.1016/j.bcp.2012.12.006
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