Denzil Bernard

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Publications (19)

• A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice
  2013 DOI: 10.1021/jm4005708
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• Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
  2013 DOI: 10.1021/ja3125417
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• High-affinity, small-molecule peptidomimetic inhibitors of mll1/wdr5 protein-protein interaction
  2013 DOI: 10.1021/ja306028q
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• Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction
  2013 DOI: 10.1021/jm3015298
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• AM-8553: A novel MDM2 inhibitor with a promising outlook for potential clinical development
  2012 DOI: 10.1021/jm3007068
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• Targeting the MDM2-p53 protein-protein interaction for new cancer therapeutics
  2012 DOI: 10.1007/978-3-642-28965-1_2
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• Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction
  2010 DOI: 10.1021/jm100139b
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• Case study: Inhibitors of the MDM2-p53 Protein-Protein Interaction
  2010 DOI: 10.1002/9780470972137.ch10
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• Split Renilla Luciferase Protein Fragment-assisted Complementation (SRL-PFAC) to characterize Hsp90-Cdc37 complex and identify critical residues in protein/protein interactions
  2010 DOI: 10.1074/jbc.M110.103390
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• Structure-based design of conformationally constrained, cell-permeable STAT3 inhibitors
  2010 DOI: 10.1021/ml100010j
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• Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer
  Sanjeev Kumar Shangary, Ke Ding, Su Qiu +10 more
  2008 DOI: 10.1158/1535-7163.MCT-08-0140
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• Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
  Sanjeev Kumar Shangary, Dongguang Qin, Donna McEachern +19 more
  2008 DOI: 10.1073/pnas.0708917105
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• Quantitative conformationally sampled pharmacophore for δ opioid ligands: Reevaluation of hydrophobic moieties essential for biological activity
  2007 DOI: 10.1021/jm0612463
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• Computer-aided drug design: Structure-activity relationships of delta opioid ligands
  2005 DOI: 10.2174/1567269054087596
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• Conformationally sampled pharmacophore for peptidic δ opioid ligands
  2005 DOI: 10.1021/jm050785p
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• Functionalization of the 6,14-bridge of the orvinols. 2. Preparation of 18- and 19-hydroxyl-substituted thevinols and their treatment with benzyl bromide
  2005 DOI: 10.1021/jo048388u
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• Position of coordination of the lithium ion determines the regioselectivity of demethylations of 3,4-dimethoxymorphinans with L-selectride
  2005 DOI: 10.1021/ol050433c
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• 2D conformationally sampled pharmacophore: A ligand-based pharmacophore to differentiate δ opioid agonists from antagonists
  2003 DOI: 10.1021/ja027644m
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• Rearrangement of 5-trimethylsilylthebaine on treatment with L-selectride: An efficient synthesis of (+)-bractazonine
  2003 DOI: 10.1021/jo020704m
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