Laura E. Gleeson
Trinity College Dublin, Royal College of Physicians of Ireland, European Respiratory Society
0000-0001-7536-3867
About
Laura graduated from Trinity College Dublin Medicine in 2010, and attained membership of the Royal College of Physicians of Ireland (MRCPI) in 2013. She completed her Higher Specialist Training in Respiratory and General Internal Medicine in 2020, before embarking upon a Clinical Fellowship in Pleural Disease and Interventional Pulmonology in Imperial NHS Trust in London.
Throughout her training, Laura was actively involved in translational medical research, and was awarded the Health Research Board's (HRB) Health Professional Fellowship to fund her PhD work examining the immunometabolic response of human macrophages to Mycobacterium tuberculosis (Mtb) infection. Through this work, she demonstrated for the first time the centrality of glycolytic reprogramming in the early innate immune response to Mtb infection, and crucially demonstrated defects in this essential immunometabolic response in alveolar macrophages from smokers' lungs.
In 2023, she was appointed as Associate Professor in Clinical Medicine, Trinity College Dublin, and Consultant Respiratory Physician in St James's Hospital. With the support of HRB funding through the Clinician Scientist Fellowship, she is exploring the role of safe, FDA-approved metabolic manipulators on the immunometabolic innate immune response to infection and the impact of macrophage ontogeny on metabolic and functional outcomes in infection, with a view to developing new treatments for TB and other respiratory pathogens.
Laura is passionate about promoting the clinical / scientific collaborations to promote truly transformative translational research that addresses questions that really matter and delivers solutions to the patient's bedside.
Employment
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Trinity College Dublin Associate Professor / Consultant Respiratory Physician2023 - Present
Education
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Royal College of Physicians of Ireland CSCST Respiratory and General Internal Medicine? - 2020
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European Respiratory Society HERMES European Diploma in Respiratory Medicine? - 2019
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Trinity College Dublin PhD? - 2017
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Royal College of Physicians of Ireland MRCPI? - 2013
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Trinity College Dublin MB BCh BAO BA? - 2010
Projects & Funding
Projects & funding information is unavailable.
Publications (35)
- Succinate enhances mitochondrial metabolism and phagocytosis in human airspace monocytes Save
- Genomic characterisation of recurrent Mycobacterium avium isolates from chronically infected patients reveals patterns of within-host evolution Save
- A retrospective analysis of five years of culture positive pleural fluid isolates in a tertiary referral centre Save
- Adequacy of pleural fluid cell block for ancillary testing in metastatic lung cancer in a “real world” setting, and factors predicting adequacy: a 5-year retrospective study Save
- Immunometabolic Reprogramming of Monocytes in Tuberculosis Infection and Disease Save
- Genomic characterisation of recurrent Mycobacterium avium isolates from chronically infected patients reveals patterns of within-host evolution Save
- Meclizine induces aerobic glycolysis in human macrophages and can enhance the glycolytic response to Mtb infection Save
- Delayed Tuberculosis Paradoxical Reaction Associated with Tumor Necrosis Factor Inhibitors. Save
- Human tissue-resident NK cells in the lung have a higher glycolytic capacity than non-tissue-resident NK cells in the lung and blood. Save
- Discordant exudates: a diagnostic dilemma Save