0000-0001-7653-9529 About
I am a formally trained paediatric neuro-oncologist and cancer geneticist, working as a full-time staff and academic-clinician at The Hospital for Sick Children (SickKids) in Toronto. I am also an Associate Member of the Brain Tumor Research Center at SickKids, Project Investigator at the Genetics and Genome Biology Program at the SickKids Research Institute, and an Assistant Professor in the Dept of Pediatrics and Institute of Medical Sciences at the University of Toronto. My over-arching goal in translational research is to unearth the germline underpinnings of deadly brain tumors in children and young adults and take these discoveries forward to improve diagnostics and clinical care for these young patients through innovative, biomarker-driven clinical trials. Specifically, my ongoing research is dedicated to comprehensively deciphering the immuno-biology of CNS cancers in children and young adults that arise from germline DNA replication-repair deficiency, and harness this data to design novel, personalized mono and combinatorial, immune-directed clinical trials for these patients. I co-lead the International RRD Consortium (https://replicationrepair.ca) with Prof. Dr. Uri Tabori and am currently involved with multiple international consortia (PBTC, CONNECT, PNOC among others) to both design clinical trials and develop biomarker analyses for RRD brain and other cancers. My translational immuno-oncology and biomarkers group is currently leading biomarker analyses for multiple clinical trials and is also foraying into a cancer interception program for children and young adults with brain tumors.
Employment
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Hospital for Sick Children
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (91)
- RAS/MAPK inhibition in pediatric gliomas Save
- Glial brain tumors in pediatric patients with germline biallelic variation in the MBD4 gene: Expanding the spectrum of MBD4-associated neoplasia syndrome Save
- Frequency and Impact of Constitutional Mismatch Repair Deficiency in Patients With High-Grade Glioma, a Retrospective Analysis of 7 Years in Pakistan: an IRRDC Study Save
- Update on Cancer Screening in Children with Syndromes of Bone Lesions, Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome, and Other Rare Syndromes Save
- Knowledge, perception and attitude of dentists regarding the role of artificial intelligence in the field of pediatric dentistry: An online questionnaire study Save
- A role for early surgical intervention in childhood low-grade glioma? Illustrative case Save
- Consortium trial demonstrates efficacy of selumetinib in pediatric low-grade glioma Save
- Trial protocol 1 from Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency Save
- Supplementary Table S1 from Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency Save
- Suppl Table S2 from Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency Save