Aishwarya Dande
Virchow Biotech Pvt. Ltd., National Institute of Pharmaceutical Education and Research, G Pulla Reddy College of Pharmacy, Osmania University
0000-0001-7673-8229
About
Ph.D. scientist with expertise in LC-HRMS based analytical workflows, integrating metabolomics, proteomics, and bioanalytical method development for pharmaceutical applications and understanding of biological systems. My doctoral research focused on nitrosamine formation and attenuation, investigated through LC-HRMS-based targeted small-molecule analysis integrated with in vitro, in vivo, and stability studies. Beyond doctoral dissertation, I have significantly contributed to multiple proteomic and metabolomic projects, involving optimization of sample preparation protocols, method development, and data interpretation using various bioinformatic tools leading to several peer-reviewed publications.
Employment
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Virchow Biotech Pvt. Ltd. Internship2020 - 2021
Education
- 2021 - 2026
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G Pulla Reddy College of Pharmacy, Osmania University Master of Pharmacy (M. Pharm)2019 - 2021
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Gokaraju Rangaraju College of Pharmacy, Osmania University Bachelor of Pharmacy (B. Pharm)2015 - 2019
Projects & Funding
Projects & funding information is unavailable.
Publications (19)
- Discovering metabolic pathways associated with immune activation in people living with HIV following ChAdOx1 nCoV-19 vaccination using mass spectrometry Save
- Effect of pH, buffers, molarity, and temperature on solution state degradation of semaglutide using LC-HRMS: A preformulation protocol for peptide drug delivery Save
- LC-ESI-HRMS-Based Evaluation of Antioxidants as Additives to Inhibit Genotoxic Nitrosamine Formation in Metformin Hydrochloride Tablets Save
- Highly selective ergosterol binding and impaired redox balance leads to improved antileishmanial efficacy for amphotericin b synthesized silver nanoparticles with reduced toxicity– In vitro and in vivo studies Save
- Risk Assessment, Detection and Control of Mutagenic Impurities in Pharmaceuticals: Emphasis on Nitrosamines Save
- Mechanistic and metabolic exploration of neohesperidin against lung cancer cell lines through ROS-mediated mitochondrial apoptosis: An in-silico and in-vitro approach Save
- Nitrosamine Drug Substance-Related Impurities (NDSRIs) in Pharmaceuticals: Formation, Mitigation Strategies, and Emphasis on Mutagenicity Risks Save
- Analytical quality by design (AQbD) in the ICHQ14 guidelines for analytical procedure development Save
- Temperature- and time-dependent degradation of mouse tissue proteins: insights into RNA-binding protein stability via mass spectrometry Save
- Identification and in vitro genotoxicity assessment of forced degradation products of glimepiride and glyburide using HEK cell‐based COMET assay Save
- Comparative analysis of plasma affinity depletion methods: Impact on protein composition and phosphopeptide abundance in human plasma Save
- Naringin and temozolomide combination suppressed the growth of glioblastoma cells by promoting cell apoptosis: network pharmacology, in-vitro assays and metabolomics based study Save
- Development and validation of high‐performance liquid chromatography‐Orbitrap mass spectrometric method for quantification of NDMA in ranitidine drug products and evaluation of antioxidants as inhibitors of classical nitrosation reaction Save
- New synergistic benzoquinone scaffolds as inhibitors of mycobacterial cytochrome bc1 complex to treat multi-drug resistant tuberculosis Save
- Comparative Evaluation of Antioxidants as Potent Inhibitors of N-nitrosodimethylamine Formation in Metformin Hydrochloride Drug Products Save
- Understanding the influence of thermal cycles on the stability of metformin HCl in presence of Sitagliptin phosphate monohydrate and polyvinyl alcohol Save
- Assessment of computational approaches in the prediction of spectrogram and chromatogram behaviours of analytes in pharmaceutical analysis: assessment review Save
- Mechanistic insight into the role of mevalonate kinase by a natural fatty acid-mediated killing of Leishmania donovani Save
- Stability Indicating Method Development and Validation for Assay of Omeprazole Sodium for Injection by a Rapid RP-HPLC Save