Dr.Ajay Kumar Raj
Mayo Clinic, Dr.D.Y.Patil Biotechnology & Bionformatic Institute, DR. D. Y. PATIL BIOTECHNOLOGY & BIOINFORMATICS INSTITUTE DR. D. Y. PATIL VIDYAPEETH, PUNE, Dr D Y Patil Vidyapeeth University
0000-0001-7690-1284
About
My investigation is mainly based on the limitations of chemotherapy upon different types of the cancer cells. However, we are trying to find alternative natural agents along with synthetic DNA repair inhibitors. from the animals gut-derived microbial fermented potential metabolites combination with synthetic drugs chemicals used against different cancer cell lines model with molecular dynamics approach.
SUMMARY OF THE RESEARCH THAT I AM PART IN MY LAB:
Research Project Title 1: THE PURPOSE OF THIS RESEARCH PROJECT IS TO DEVELOP AND VALIDATE A NEW VERTICAL TUBE GEL ELECTROPHORESIS (VTGE) SYSTEM THAT WILL HELP US UNDERSTAND THE POTENTIAL METABOLITES THAT ARE INDUCE CELL DEATH AND APOPTOSIS IN CANCERCELLS.
Goal:
• To develop detection tools for the early detection of oral and breast cancer by using VTGE and LC-HRMS
• To investigate fundamental studies that lead to understanding of the nature has given us many potential chemotherapies in the forms of free fatty acid, peptides ,polyphenolic metabolites that are used as deity source.
Research Project Title 2: TO EXPLORE POTENTIAL OF DNA REPAIR INHIBITORS TO LIFT THE BURDEN OF HIGH DOSE CHEMOTHERAPEUTIC DRUGS IN CARCINOMA
Goal:
• To revisit the differential loss and high dose aspects of well-known chemotherapy drugs.
• To investigate the cellular and molecular aspects of possible lowering the dose of genotoxic drugs and concomitantly appreciable retardation to carcinoma proliferation and possible cell death.
• To dissect out the molecular basis of such observations using cellular and molecular tools.
• To investigate the molecular, genetic and epigenetic changes due to microenvironment cross-talk.
Employment
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Mayo Clinic Postdoctoral2022 - 2027
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Dr.D.Y.Patil Biotechnology & Bionformatic Institute Ph.D Scholar2016 - 2019
Education
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DR. D. Y. PATIL BIOTECHNOLOGY & BIOINFORMATICS INSTITUTE DR. D. Y. PATIL VIDYAPEETH, PUNE Ph.D. Scholar2018 - 2022
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Dr D Y Patil Vidyapeeth University MASTER IN BIOTECHNOLOGY2014 - 2016
Projects & Funding
Projects & funding information is unavailable.
Publications (25)
- Modulation of Urinary Lipid Peroxidation Products in Breast Cancer and Design of Mimetic 4-HNE (4-HNEM) as SIRT2 Inhibitor Save
- Elevated N1-Acetylspermidine Levels in Doxorubicin-treated MCF-7 Cancer Cells: Histone Deacetylase 10 Inhibition with an N1-Acetylspermidine Mimetic Save
- Intracellular Ellagic Acid Derived from Goat Urine DMSO Fraction (GUDF) Predicted as an Inhibitor of c-Raf Kinase Save
- Secretion of Sphinganine by Drug-Induced Cancer Cells and Modified Mimetic Sphinganine (MMS) as c-Src Kinase Inhibitor Save
- Free Fatty Acids from Cow Urine DMSO Fraction Induce Cell Death in Breast Cancer Cells without Affecting Normal GMSCs Save
- Predicted Role of Acetyl-CoA Synthetase and HAT p300 in Extracellular Lactate Mediated Lactylation in the Tumor: In vitro and In silico Models Save
- Reduced Level of Prolylhydroxyproline in the Nail Clippings of Oral Cancer Patients and its Role as an Activator of Phospholipase C-β2 Save
- Detection of nail oncometabolite SAICAR in oral cancer and its molecular interactions with PKM2 enzyme Save
- A novel method to detect intracellular metabolite alterations in MCF-7 cells by doxorubicin induced cell death Save
- An Intracellular Tripeptide Arg-His-Trp of Serum Origin Detected in MCF-7 Cells is a Possible Agonist to β2 Adrenoceptor Save