0000-0001-7751-1181 About
My Ph.D. research was focused on the structural-dynamic features of CCL2 chemokines from murine and humans and unraveling the molecular interactions between various plant-based products such as flavonoids and CCL2 orthologs. In this work, I have cloned, expressed, and purified human and murine CCL2 proteins using multiple chromatographic techniques such as affinity chromatography and ion exchange chromatography. I have also conducted extensive structural and biophysical studies on CCL2 ortholog proteins using solution-state NMR, circular dichroism, fluorescence spectroscopy, and molecular docking. Apart from that, I have also carried out cell-based assays to detect the antimicrobial activity of various compounds using MIC assays and UV-Vis spectroscopy for my collaboration work. Moreover, as an RA in the school of biotechnology at Jawaharlal Nehru University (JNU), I have performed computational work. I have used extensive bioinformatics tools such as SWISS-MODEL, Chimera, PyMol, SAVES, SPDV, AutoDock, HADDOCK LigPlot, Avogadro, and many more to model, design, and screen potential selective inhibitors of amoebic proteasomes.
Currently, I am working as a Postdoctoral Scientist at the University of Minnesota. My research uses multi-dimensional NMR spectroscopy and other biophysical techniques to unravel the structural and dynamic features of the kinases, specifically the Aurora A kinase and the c-Myc proto-oncogene.
Employment
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University of Minnesota Postdoctral Associate2021 - Present
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Jawaharlal Nehru University Research Associate2021 - 2021
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (13)
- The 26 S proteasome in Entamoeba histolytica: divergence of the substrate binding pockets from host proteasomes Save
- Halogenated Secondary Metabolites from Higher Plants: Potent Drug Candidates for Chikungunya Using in silico Approaches Save
- Computational probing of Nigella sativa bioactive metabolites against chickungunya nsP2 cysteine protease Save
- Gallate Moiety of Catechin Is Essential for Inhibiting CCL2 Chemokine-Mediated Monocyte Recruitment Save
- Deciphering the Potential of Pre and Pro-Vitamin D of Mushrooms against Mpro and PLpro Proteases of COVID-19: An In Silico Approach Save
- Hydroxyl Groups on Annular Ring-B Dictate the Affinities of Flavonol–CCL2 Chemokine Binding Interactions Save
- Elucidating the Molecular Interactions of Chemokine CCL2 Orthologs with Flavonoid Baicalin. Save
- Molecular insights into the differential structure-dynamics-stability features of interleukin-8 orthologs: Implications to functional specificity. Save
- Dissecting the differential structural and dynamics features of CCL2 chemokine orthologs. Save
- Antimicrobial selectivity of ruthenium, rhodium, and iridium half sandwich complexes containing phenyl hydrazone Schiff base ligands towards B. thuringiensis and P. aeruginosa bacteria Save