Lindsey Van Haute

Employment

Employment history is unavailable.

Education

• Vrije Universiteit Brussel PhD Medical Sciences - Genetics and Regenerative Medicine
  ? - 2013
• Universiteit Antwerpen Master Human Biology
  ? - 2003

Projects & Funding

• Mitochondrial genome editing European Molecular Biology Organization
• Differentiation of human embryonic stem cells Fonds Wetenschappelijk Onderzoek

Publications (25)

• Transcriptome Sequencing Reveals the Mechanism behind Chemically Induced Oral Mucositis in a 3D Cell Culture Model
  International Journal of Molecular Sciences 2023 DOI: 10.3390/ijms24055058
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• TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease
  Lindsey Van Haute, Emily O’Connor, Héctor Díaz-Maldonado +38 more
  Nature Communications 2023 DOI: 10.1038/s41467-023-36277-7
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• A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome.
  Nature biomedical engineering 2022 DOI: 10.1038/s41551-022-00968-1
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• A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit
  Nature Communications 2022 DOI: 10.1038/s41467-022-28503-5
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• In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue
  Nature Communications 2022 DOI: 10.1038/s41467-022-28358-w
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• The FASTK family proteins fine-tune mitochondrial RNA processing.
  PLoS genetics 2021 DOI: 10.1371/journal.pgen.1009873
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• YbeY is required for ribosome small subunit assembly and tRNA processing in human mitochondria.
  Nucleic acids research 2021 DOI: 10.1093/nar/gkab404
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• Quantitative density gradient analysis by mass spectrometry (qDGMS) and complexome profiling analysis (ComPrAn) R package for the study of macromolecular complexes.
  Biochimica et biophysica acta. Bioenergetics 2021 DOI: 10.1016/j.bbabio.2021.148399
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• Detection of 5-formylcytosine in Mitochondrial Transcriptome.
  Methods in molecular biology (Clifton, N.J.) 2021 DOI: 10.1007/978-1-0716-0834-0_5
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• METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis.
  Nucleic acids research 2019 DOI: 10.1093/nar/gkz735
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• NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs.
  Nucleic acids research 2019 DOI: 10.1093/nar/gkz559
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• The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
  Nucleic acids research 2019 DOI: 10.1093/nar/gkz454
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• The mammalian mitochondrial epitranscriptome.
  Biochimica et biophysica acta. Gene regulatory mechanisms 2018 DOI: 10.1016/j.bbagrm.2018.11.005
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• Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.
  Nature medicine 2018 DOI: 10.1038/s41591-018-0165-9
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• Maturation of selected human mitochondrial tRNAs requires deadenylation.
  eLife 2017 DOI: 10.7554/elife.27596
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• Regulation of Mammalian Mitochondrial Gene Expression: Recent Advances.
  Trends in biochemical sciences 2017 DOI: 10.1016/j.tibs.2017.02.003
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• Dealing with an Unconventional Genetic Code in  Mitochondria: The Biogenesis and Pathogenic  Defects of the 5-Formylcytosine Modification in  Mitochondrial tRNAMet.
  Biomolecules 2017 DOI: 10.3390/biom7010024
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• Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.
  Nucleic acids research 2016 DOI: 10.1093/nar/gkw676
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• Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3.
  Nature communications 2016 DOI: 10.1038/ncomms12039
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• Engineered mtZFNs for Manipulation of Human Mitochondrial DNA Heteroplasmy.
  Methods in molecular biology (Clifton, N.J.) 2016 DOI: 10.1007/978-1-4939-3040-1_11
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