Arindam Mondal
Indian Institute of Technology Kharagpur, University of Wisconsin-Madison, University of Calcutta, University of Virginia
0000-0001-7991-5809
About
I am a virologist with extensive experience of working with RNA viruses that cause epidemic and pandemic outbreaks in humans. Using different influenza viruses as model organism (influenza A (H1N1/ H17N10), influenza B) we study the structure function relationship of macromolecular machineries that drives viral entry and replication within the host cell. We are also interested in understanding how alteration in viral antigens, through antigenic shift and antigenic drifts, drives viral evolution and cross species transmission in human.
During my masters in chemistry, I became intrigued by complex macromolecular assemblies of proteins and nucleic acids in different biological systems. This drove me to pursue my PhD in biological science from the Department of Biochemistry, University of Calcutta, where I got introduced to viruses. Major focus of my PhD research was to elucidate the detailed molecular mechanism by which RNA viruses assemble their replication machinery in the form of Ribonucleoprotein complexes. After PhD, I did my postdoctoral research work at University of Virginia and subsequently at University of Wisconsin Madison. During my postdoctoral tenure I discovered complex interplay between virus and host kinases which regulate replication of viral genome and hence determines the ultimate fate of virus infection.
Currently I am working as an assistant professor in the School of Bioscience Indian Institute of Technology Kharagpur and leading the “Molecular Virology Group”, where we are focussed upon developing therapeutics, prophylactics and diagnostics strategies to prevent respiratory virus infections. Using influenza virus as the model organism, we study “viral-entry” and “virus-replication” in a wide variety of host species in order to understand their evolution and host adaptation strategies in molecular detail. This in turn leads to the identification of evolutionarily conserved hotspots in viral antigens which could be targeted for the development of broad spectrum antivirals. The same hotspots could also serve as molecular markers for precise identification of virus infection in patients, thereby leading to the development of highly specific diagnostics technologies.
Employment
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Indian Institute of Technology Kharagpur Assistant Professor2016 - Present
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University of Wisconsin-Madison Assistant Scientist2016 - 2016
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University of Wisconsin-Madison Research Associate2013 - 2015
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University of Virginia Postdoctoral fellow2011 - 2012
Education
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University of Calcutta PhD2005 - 2011
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University of Calcutta MSc2003 - 2005
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University of Calcutta BSc2000 - 2003
Projects & Funding
Projects & funding information is unavailable.
Publications (25)
- Influenza virus Non Structural protein 1 (NS1) Chaperones Nucleoprotein (NP) Oligomerization to Coordinate Ribonucleoprotein Assembly and Genome Replication Save
- Host Protein Kinase C⍺: The novel Mitogen Activated Protein Kinase (MAPK) specific scaffold regulating nuclear export of influenza virus ribonucleoprotein complexes Save
- Identification of novel thiazole derivatives as flaviviral protease inhibitors effective against Dengue (DENV2) and Japanese encephalitis viruses Save
- Identification of novel thiazole derivatives as flaviviral protease inhibitors against DENV and JEV Save
- Unveiling the role of host kinases at different steps of influenza A virus life cycle Save
- Ho3+-Doped Carbon Dot/Gelatin Nanoparticles for pH-Responsive Anticancer Drug Delivery and Intracellular Cu2+ Ion Sensing Save
- Dihydropyrrolo[3,2-b]pyrrole-3,6-dicarbaldehyde-Based Two-Photon-Responsive Nanoparticles for Effective Photodynamic Therapy Save
- Green Light-Activated Single-Component Organic Fluorescence-Based Nano-Drug Delivery System for Dual Uncaging of Anticancer Drugs Save
- Targeting an evolutionarily conserved “E-L-L” motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2 Save
- The Species-Specific 282 Residue in the PB2 Subunit of the Polymerase Regulates RNA Synthesis and Replication of Influenza A Viruses Infecting Bat and Nonbat Hosts Save