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Dr. Shivani Srivastava, Ph.D.

Yale University, University of California, Banaras Hindu University, The Ohio State University

ORCID iD 0000-0001-8042-4476
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About

Shivani Srivastava earned her Ph.D. in Biochemistry from the Institute of Medical Sciences, BHU, India, where her doctoral research focused on the molecular mechanisms of diabetes, with particular emphasis on pancreatic β-cell and intestinal adaptation, incretin hormones, and phytotherapeutic modulation of metabolic pathways. This work provided rigorous training in metabolic and endocrine biology and established a long-standing interest in understanding how cellular stress responses contribute to metabolic disease.

In March 2020, she moved to the United States to further expand her research training. She initially worked at The Ohio State University and later at UCLA, where she explored the cellular and molecular pathways connecting metabolic dysregulation to cardiovascular disease progression. She then joined Yale University, where her research has focused on rare skeletal and metabolic disorders, including Hutchinson-Gilford progeria syndrome, ENPP1-associated obesity and metabolic dysfunction, and disorders of pathological mineralization. Her research has contributed to the development of bone-targeted ENPP1 enzyme replacement therapy, demonstrating restoration of hearing through correction of auditory ossicle mineralization (co-first author, PMID: 40495691) and amelioration of spinal hyperostosis and enthesopathy in preclinical models of ossification of the posterior longitudinal ligament (OPLL) (PMID: 41251406). Using genetically engineered mouse models, in vitro approaches, and stem cell differentiation assays, her work examines how metabolic enzymes and disease-associated genetic variants regulate skeletal mineralization, adipose biology, and systemic metabolic homeostasis. These studies aim to uncover disease mechanisms and evaluate therapeutic potential.

By integrating disease-relevant preclinical models with mechanistic studies, her research seeks to bridge basic science and clinical translation in the fields of bone disease, metabolic diseases (including diabetes and obesity), and cardiovascular disease.

Media Coverage & Institutional Recognition:

1) Braddock Lab Sheds Light on Two Debilitating Spinal Disorders (Yale School of Medicine) (https://medicine.yale.edu/lab/braddock/news-article/braddock-lab-sheds-light-on-two-debilitating-spinal-disorders/)

2) Shivani Srivastava Receives the 2024 Young Investigator Award (Yale School of Medicine) (https://medicine.yale.edu/news-article/shivani-srivastava-2024-young-investigator-award/)

3) Novel Enzyme Replacement Therapy Restores Hearing Loss (Yale School of Medicine) (https://medicine.yale.edu/lab/braddock/news-article/novel-enzyme-replacement-therapy-restores-hearing-loss/)

4) Srivastava Named Guest Editor for Diabetology Special Issue (Yale School of Medicine) (https://medicine.yale.edu/news-article/srivastava-named-guest-editor-for-diabetology-special-issue/)

5) New Enzyme Developed at Yale Offers Hope for Patients with Lupus (Yale News) (https://news.yale.edu/2024/06/20/new-enzyme-developed-yale-offers-hope-patients-lupus)

6) Yale Research Reveals Novel Pathways Regulating Mammalian Bone Mass (Yale School of Medicine) (https://medicine.yale.edu/lab/braddock/news-article/yale-research-reveals-novel-pathways-regulating-mammalian-bone-mass/)

7) Influential Women: Shivani Srivastava, Emerging Biomedical Scientist Advancing Research on Metabolic Diseases (Influential Women Press) (https://influentialwomen.press/influential-women-shivani-srivastava-emerging-biomedical-scientist-advancing-research-on-metabolic-diseases/)

Employment

  • Yale University Associate Research Scientist (Non-Tenure Research Faculty Appointment)
    2025 - 2026
  • Yale University Postdoctoral Associate
    2022 - 2025
  • University of California Postdoctoral Scholar
    2021 - 2022
  • The Ohio State University Postdoctoral Scholar
    2020 - 2021
  • Banaras Hindu University Voluntary Research Scientist
    2019 - 2020
  • Banaras Hindu University Guest Faculty
    2016 - 2017
  • Indian Council of Agricultural Research Senior Research Fellow
    2012 - 2013

Education

  • Banaras Hindu University Ph.D (Biochemistry)
    ? - 2019
  • Banaras Hindu University M.Sc (Biochemistry)
    ? - 2011
  • Banaras Hindu University B.Sc (Hons.) (Botany, Zoology, Chemistry)
    ? - 2009

Projects & Funding

Projects & funding information is unavailable.

Publications (31)