Guo-Jun Chen

Employment

• Chongqing Medical University PI/Professor
  2011 - Present
• University of Pittsburgh Research Scientist
  2007 - 2011
• SUNY College at Buffalo Postdoctorate
  2002 - 2007
• Brown University Postdoctorate
  2001 - 2002

Education

• Huashan Hospital Fudan University Ph.D
  1993 - 1996
• Chongqing Medical University M.D.
  1988 - 1991

Projects & Funding

Projects & funding information is unavailable.

Publications (75)

• STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells.
  Experimental neurology 2024 DOI: 10.1016/j.expneurol.2024.114805
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• SHMT2 Mediates Small-Molecule-Induced Alleviation of Alzheimer Pathology Via the 5'UTR-dependent ADAM10 Translation Initiation.
  Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 DOI: 10.1002/advs.202305260
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• MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway.
  The Journal of biological chemistry 2024 DOI: 10.1016/j.jbc.2024.107530
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• Cerebral furin deficiency causes hydrocephalus in mice.
  Genes & diseases 2023 DOI: 10.1016/j.gendis.2023.04.037
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• ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation.
  Proceedings of the National Academy of Sciences of the United States of America 2023 DOI: 10.1073/pnas.2220148120
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• DEAD-Box Helicase 17 Promotes Amyloidogenesis by Regulating BACE1 Translation.
  Brain sciences 2023 DOI: 10.3390/brainsci13050745
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• TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: An in vitro study.
  Neuroscience letters 2023 DOI: 10.1016/j.neulet.2023.137265
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• Apicidin attenuates memory deficits by reducing the Aβ load in APP/PS1 mice.
  CNS neuroscience & therapeutics 2023 DOI: 10.1111/cns.14102
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• HMGCS2-Induced Autophagic Degradation of Tau Involves Ketone Body and ANKRD24.
  Journal of Alzheimer's disease : JAD 2023 DOI: 10.3233/jad-220640
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• AP2S1 regulates APP degradation through late endosome-lysosome fusion in cells and APP/PS1 mice.
  Traffic (Copenhagen, Denmark) 2022 DOI: 10.1111/tra.12874
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