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Thierry Alquier
Université de Montréal, Centre Hospitalier de l'Université de Montréal Centre de Recherche, Université Paul Sabatier Toulouse III UFR PCA, Université Toulouse III - Paul Sabatier
Research areas: Medicine · Endocrinology, Diabetes and Metabolism · Regulation of Appetite and Obesity · Pancreatic function and diabetes · Diabetes Treatment and Management
0000-0001-8171-802X
Employment
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Université de Montréal Professor2022 - Present
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Centre Hospitalier de l'Université de Montréal Centre de Recherche Head, Cardiometabolic research2017 - 2025
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Université de Montréal Associate Professor2016 - Present
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Université de Montréal Assistant Professor2009 - 2016
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Université de Montréal Postdoctoral fellow (CDA)2006 - 2009
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Harvard Medical School Postdoctoral fellow (ADA-EASD)2003 - 2006
Education
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Université Paul Sabatier Toulouse III UFR PCA PhD1999 - 2002
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Université Paul Sabatier DEA (Master equivalent)1998 - 1999
Projects & Funding
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Central control of energy homeostasis by neuronal adipose triglyceride lipase Canadian Institutes of Health Research2021 - 2026
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Microglial fatty acid signalling as a modulator of diet-induced neuroimmune responses in obesity Canadian Institutes of Health Research2020 - 2025
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Contrôle hypothalamique de la balance énergétique par les lipides et physiopathologie de l'obésité Fonds de Recherche du Québec - Santé2018 - 2023
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Gliopeptidic regulation of hypothalamic neuronal circuitry by endozepines and energy balance Canadian Institutes of Health Research2017 - 2022
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Targeting alpha-beta-hydrolase domain 6 in the neural control of body weight, reward and mood Canadian Institutes of Health Research2017 - 2020
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Correction of brain triglyceride metabolism in Alzheimer's disease Canadian Institutes of Health Research2016 - 2021
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Central lipid signalling and regulation of energy balance Canada Foundation for Innovation2012 - Present
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Role of the hypothalamo-pancreatic axis in the pathogenesis of type 2 diabetes Canadian Institutes of Health Research2011 - 2015
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Role of the hypothalamo-pancreatic axis in the pathogenesis of type 2 diabetes Canadian Institutes of Health Research2011 - 2011
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Rôle de l axe hypothalamo-pancréatique dans la pathogénie du diabète de type 2 Fonds de Recherche du Québec2010 - 2014
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Rôle de l axe hypothalamo-pancréatique dans la pathogénie du diabète de type 2 Fonds de Recherche du Québec2010 - 2013
Publications (67)
- Dietary fructose promotes anxiety through impairment of microglia physiology Save
- Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis Save
- Anxiety induced by systemic inflammation involves microglial engulfing of nucleus accumbens inputs and diminished excitability of dopamine D1 receptor neurons Save
- DGAT1-dependent lipid droplet synthesis in microglia attenuates neuroinflammatory responses to lipopolysaccharides Save
- A consensus guide to preclinical indirect calorimetry experiments Save
- A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in male and female mice Save
- Blockage of ATGL-mediated breakdown of lipid droplets in microglia alleviates neuroinflammatory and behavioural responses to lipopolysaccharides Save
- ABHD6 loss-of-function in mesoaccumbens postsynaptic but not presynaptic neurons prevents diet-induced obesity in male mice Save
- Central activation of the fatty acid sensor GPR120 suppresses microglia reactivity and alleviates sickness- and anxiety-like behaviors Save
- 16p11.2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice Save
- Role of astroglial ACBP in energy metabolism flexibility and feeding responses to metabolic challenges in male mice Save
- Role of astroglial ACBP in energy metabolism flexibility and feeding responses to metabolic challenges in male mice Save
- The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice Save
- From benzodiazepines to fatty acids and beyond: revisiting the role of ACBP/DBI Save
- Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity Save
- Distinct Basal Metabolism in Three Mouse Models of Neurodevelopmental Disorders Save
- Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice Save
- Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice Save
- In vivo Ultrafast Quantitative Ultrasound and Shear Wave Elastography Imaging on Farm-Raised Duck Livers during Force Feeding Save
- Neuronal control of peripheral nutrient partitioning Save