Narendra Singh

About

I am interested in understanding the role of transcription factors and gene regulatory networks in the determination of cellular identity using Hox genes as a paradigm. During my Ph.D., I uncovered specific roles of cis-regulatory elements in chromatin organization and the expression of Hox genes to determine body patterning in Drosophila. In my Postdoctoral research, I used cross-species functional analysis to find how paralogous genes undergo functional diversification while also retaining the ancestral function during vertebrate evolution. In the future, I want to understand deeper how sequence divergence in transcription factor paralogs lead to functional and phenotypic novelties during evolution.

Employment

• National Heart Lung and Blood Institute
  2021 - Present
• Stowers Institute for Medical Research Senior Research Associate
  2014 - 2021

Education

• Centre for Cellular and Molecular Biology Phd
  2006 - 2014

Projects & Funding

Projects & funding information is unavailable.

Publications (16)

• Diversification and Functional Evolution of HOX Proteins
  Frontiers in Cell and Developmental Biology 2022 DOI: 10.3389/fcell.2022.798812
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• Genome-wide analysis of cis-regulatory changes underlying metabolic adaptation of cavefish
  Nature Genetics 2022 DOI: 10.1038/s41588-022-01049-4
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• Gene regulation: Context is everything
  Current Biology 2021 DOI: 10.1016/j.cub.2021.08.064
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• Genome-Wide Binding Analyses of HOXB1 Revealed a Novel DNA Binding Motif Associated with Gene Repression
  Journal of Developmental Biology 2021 DOI: 10.3390/jdb9010006
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• A six-amino-acid motif is a major determinant in functional evolution of HOX1 proteins
  Genes & Development 2020 DOI: 10.1101/gad.342329.120
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• HSPB5 (αB-crystallin) confers protection against paraquat-induced oxidative stress at the organismal level in a tissue-dependent manner.
  Cell stress & chaperones 2020 DOI: 10.1007/s12192-020-01171-4
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• Genome-wide binding analyses of HOXB1 revealed a novel DNA binding motif associated with gene repression
  bioRxiv 2020 DOI: 10.1101/2020.12.29.424720
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• HOXA1 and TALE proteins display cross-regulatory interactions and form a combinatorial binding code on HOXA1 targets.
  Genome research 2017 DOI: 10.1101/gr.219386.116
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• Hox Genes:Let's Work Together
  Proceedings of the Indian National Science Academy 2016 DOI: 10.16943/ptinsa/2016/v82/48403
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• Specific combinations of boundary element and Polycomb response element are required for the regulation of the Hox genes in Drosophila melanogaster.
  Mechanisms of development 2015 DOI: 10.1016/j.mod.2015.07.016
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