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Deepanjan Datta

Manipal Academy of Higher Education, Lloyd Institute of Management and Technology, Birla Institute of Technology, Mesra

ORCID iD 0000-0001-8398-4276
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About

Dr. Deepanjan is currently working as an assistant professor at Manipal Academy of Higher Education, Manipal, Karnataka. He has made contributions to the field of biological barriers and drug delivery throughout his Ph.D. journey. His research has advanced a fundamental understanding of biological barriers and has led to the development of new materials as well as technologies for the diagnosis and treatment of various ailments, including ocular diseases, skin diseases, and infectious diseases, among others. Also, his working experience in Dr. Reddy’s laboratories has made him understand and gain knowledge, particularly in the topical and transdermal fields. At the same time, fundamental understanding developed through his research has advanced the understanding of the biology of barriers in the human body. His research is outlined below in the following areas:

Skin and Transdermal drug delivery
Dr. Deepanjan has a fundamental knowledge base of the transport properties of peptides across and into the skin. Previously, he has fabricated and characterised stimuli-responsive interpenetrating polymeric network (IPN) patch-loaded antibiotic and antiprotozoal model drugs that can be used to treat infections pertaining to reproductive system, gastrointestinal tract, skin, heart, bone, joint, lung, blood, nervous system, and other areas of the body. Lately, he has worked with biological membranes such as porcine skin tissue to study the skin permeation of peptides (antibiotics and immunosuppressants). Further, he has used novel technologies to enable transdermal delivery of peptides or proteins that otherwise have to be administered orally or injected using needles. He has worked with permeation enhancers, which make it feasible for drugs to permeate across intact and tape-stripped skin. Nonetheless, he has also used ionic liquids for the skin transport of peptides. Also, he has developed ionic liquid organogel systems to be applied on the human skin for the treatment of moderate to severe psoriasis, atopic dermatitis, and blistering disorders, among others. The prepared ionic liquids organogel system has showed significant permeation of drug across the skin, with a significant amount in the blood when compared to the marketed intravenous dosage forms, in pharmacokinetic studies. Deepanjan’s research has made it possible to deliver macromolecules in non-invasive fashion using transdermal patches, which was previously considered not feasible. He with his Ph.D. supervisor Prof. Venkata Vamsi Krishna Venuganti also designed a novel ionic liquid transdermal patch, simultaneously capable of disrupting biological barrier, stratum corneum and delivering drugs into the skin.

Ocular Drug Delivery
Dr. Deepanjan have also worked in ocular field where he has developed dissolvable microneedle contact lens design for the first time. This contact lens device helped in the penetration of peptide model drug across the anterior and posterior segment of an eye, to treat various ocular infections such as uveitis, corneal healing, vernal keratoconjunctivitis and other inflammatory diseases. The fabrication of contact lens device showed to achieve therapeutic level within the tissues, thereby bypassing the need of injecting hypodermic needles into the cornea. The model macromolecule loaded in microneedle ocular patch in a bi-layered approach, showed efficient mechanical properties, loading, dissolution, corneal insertion, and its distribution in excised porcine eye globe. This unique fabricated formulation showed significant permeation and retention when compared with commercially available eye drops.

Employment

  • Manipal Academy of Higher Education Assistant Professsor
    2023 - Present
  • Lloyd Institute of Management and Technology Research Assistant Professor
    2022 - 2023

Education

  • Birla Institute of Technology, Mesra M. Pharm
    2014 - 2016

Projects & Funding

Projects & funding information is unavailable.

Publications (30)