Neeraj Sharma
Johns Hopkins University School of Medicine, Postgraduate Institute of Medical Education and Research, College of Veterinary Medicine
0000-0001-8474-3714
About
I am an Assistant Professor of Genetic Medicine at Johns Hopkins University School of Medicine, with 23 years dedicated to advancing precision medicine for cystic fibrosis (CF). My laboratory develops models—including minigenes, human primary airway, and sweat gland cultures—to study splice-site and nonsense variants unresponsive to modulators. Using these models, we test strategies such as mRNA decay inhibition, splicing correction, and readthrough combined with modulators to inform new CF therapies. I hold a Doctor of Veterinary Medicine (DVM), a Master’s in Veterinary Medicine, and a PhD in CF research, followed by six years of postdoctoral training under Prof. Garry Cutting at Johns Hopkins. I now lead a research program focused on developing treatments for all individuals with CF.
Employment
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Johns Hopkins University School of Medicine Assistant Professor2021 - Present
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Johns Hopkins University School of Medicine Instructor2016 - 2020
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Johns Hopkins University School of Medicine Research Associate2014 - 2016
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Johns Hopkins University School of Medicine Postdoctoral fellow2008 - 2014
Education
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Postgraduate Institute of Medical Education and Research PhD2003 - 2008
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College of Veterinary Medicine MVSc2000 - 2002
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College of Veterinary Medicine DVM1995 - 2000
Projects & Funding
Projects & funding information is unavailable.
Publications (34)
- Clinical, functional and therapeutic evaluation of CFTR variant I507del Save
- CFTR Gene Regulation in Human Pancreatic Duct, Bile Duct and Sweat Gland Epithelial Cells Save
- Ligand-free biodegradable poly(beta-amino ester) nanoparticles for targeted systemic delivery of mRNA to the lungs Save
- Establishment of a conditionally reprogrammed primary eccrine sweat gland culture for evaluation of tissue-specific CFTR function Save
- Investigation of CFTR Function in Human Nasal Epithelial Cells Informs Personalized Medicine Save
- Extracellular vesicles enhance pulmonary transduction of stably associated adeno-associated virus following intratracheal administration Save
- Protospacer modification improves base editing of a canonical splice site variant and recovery of CFTR function in human airway epithelial cells Save
- Use of adenine base editing and homology-independent targeted integration strategies to correct the cystic fibrosis causing variant, W1282X Save
- CFTR bearing variant p.Phe312del exhibits function inconsistent with phenotype and negligible response to ivacaftor Save
- Downstream Alternate Start Site Allows N-Terminal Nonsense Variants to Escape NMD and Results in Functional Recovery by Readthrough and Modulator Combination Save