VM
vasco meneghini
Università Vita-Salute San Raffaele Facoltà di Medicina e Chirurgia, San Raffaele Hospital, Università degli Studi del Piemonte Orientale Amedeo Avogadro Dipartimento di Scienze del Farmaco
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Virus-based gene therapy research · CRISPR and Genetic Engineering · Neurogenesis and neuroplasticity mechanisms
0000-0001-8506-6495
Employment
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Università Vita-Salute San Raffaele Facoltà di Medicina e Chirurgia Ricercatore universitario a t.d.2022 - Present
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San Raffaele Hospital Project Leader2019 - Present
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institut imagine Post-Doc2014 - 2019
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Ospedale San Raffaele Post-Doc2011 - 2014
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Università degli Studi del Piemonte Orientale Amedeo Avogadro Dipartimento di Scienze del Farmaco Post-Doc2010 - 2011
Education
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Università degli Studi del Piemonte Orientale Amedeo Avogadro Dipartimento di Scienze del Farmaco PhD2006 - 2010
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Universita degli Studi di Milano-Bicocca Master Degree (2nd level) in Industrial Biotechnology2003 - 2006
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Universita degli Studi di Milano-Bicocca Degree (1st level) in Molecular Biotechnology1999 - 2003
Projects & Funding
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Identification of clinically relevant hiPSC-derived neural stem cell populations for cell therapies of neurodegenerative disorders 10x Genomics2019 - Present
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Combination of lentiviral and genome editing technologies for the treatment of sickle cell disease SATT IDF Innov2017 - 2019
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hiPSC-based platform to optimize CRISPR/Cas9-mediated genome editing approaches in sickle cell disease Campus France2015 - 2016
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Gene therapy for Methachromatic Leukodystrophy Fondazione Telethon2011 - 2012
Publications (41)
- Cross-Correction in HSC Gene Therapy for Metachromatic Leukodystrophy Save
- Targeting white matter astrocytes with a Gfap-disruptive Cas9 nuclease benefits a murine model of Alexander disease Save
- AAV vectors trigger DNA damage response-dependent pro-inflammatory signalling in human iPSC-derived CNS models and mouse brain Save
- Human iPSC-derived neural stem cells displaying radial glia signature exhibit long-term safety in mice Save
- AAV vectors trigger DNA damage responses and STING-dependent inflammation in human CNS cells Save
- Human iPSC-derived neural stem cells display a radial glia-like signaturein vitroand favorable long-term safety in transplanted mice Save
- Editorial: Ex-vivo and in-vivo genome engineering for metabolic and neurometabolic diseases Save
- Investigating the Role of Vector DNA Sensing and Transgene Expression on Innate Immune Signaling and Cell Toxicity upon AAV-Mediated Gene Transfer in hiPSC-Derived CNS Models Save
- Intracerebroventricular transplantation of human iPSC-derived neural stem cells (hiPSC-NSCs) into neonatal mice. Save
- Developing Allele-Specific Gene Editing Technologies for Silencing or Precise Correction of GFAP Mutations Causing Alexander's Disease Save
- Exploring the identity and safety of hiPSC-derived neural stem/progenitor cells: implications for cell therapy approaches Save
- Investigating the Role of Innate Immune Signaling in AAV-Mediated Gene Transfer in hiPSC-Derived CNS Models Save
- Investigating the role of innate immune signaling in cell toxicity upon AAV-mediated gene transfer in hiPSC-derived CNS models Save
- Combination of lentiviral and genome editing technologies for the treatment of sickle cell disease. Save
- Delivery Platforms for CRISPR/Cas9 Genome Editing of Glial Cells in the Central Nervous System. Save
- Development of cutting-edge editing technologies to treat Alexander disease Save
- Development of editing technologies for allele-specific silencing or precise correction of mutation hotspots affecting Alexander disease's patients Save
- Dissecting the Transcriptional and Epigenetic Landscape of hiPSC-Derived Neural Stem and Progenitor Cells: Implications for Cell Therapy Approaches Save
- In vivo Gene Therapy to the Liver and Nervous System: Promises and Challenges. Save
- Human iPSC-Based Models for the Development of Therapeutics Targeting Neurodegenerative Lysosomal Storage Diseases. Save