Pratibha Srivastava

About

Pratibha Srivastava is a molecular biologist specializing in the development of therapeutic pancreatic beta cells with enhanced robustness and functionality. Utilizing cutting-edge CRISPR gene editing technology, Pratibha engineers have induced pluripotent stem cell (iPSC) lines to create next-generation beta cells, aiming to revolutionize treatments for Diabetes. Their work focuses on improving the viability and performance of these cells, addressing critical challenges in regenerative medicine and cell therapy. With a deep commitment to advancing translational science, Pratibha contributes to the growing field of precision medicine by bridging molecular biology, stem cell technology, and genome engineering.

Employment

• Children's Hospital of Philadelphia Postdoctoral Researcher
  2023 - Present
• University of Pennsylvania PostDoctoral Researcher
  2022 - 2023

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (8)

• The Mediator subunit <scp>MED12</scp> promotes formation of <scp>HSF1</scp> condensates on heat shock response element arrays in heat‐shocked cells
  FEBS Letters 2023 DOI: 10.1002/1873-3468.14617
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• MED12 interacts with the heat‐shock transcription factor HSF1 and recruits CDK8 to promote the heat‐shock response in mammalian cells
  FEBS Letters 2021 DOI: 10.1002/1873-3468.14139
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• HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response
  FEBS Open Bio 2020 DOI: 10.1002/2211-5463.12863
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• The pericentromeric protein shugoshin 2 cooperates with HSF 1 in heat shock response and RNA Pol II recruitment
  The EMBO Journal 2019 DOI: 10.15252/embj.2019102566
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• Differential Proteome Analysis of Chikungunya Virus and Dengue Virus Coinfection in Aedes Mosquitoes
  Journal of Proteome Research 2018 DOI: 10.1021/acs.jproteome.8b00211
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• Poly(ADP-Ribose) Polymerase 1 Promotes the Human Heat Shock Response by Facilitating Heat Shock Transcription Factor 1 Binding to DNA
  Molecular and Cellular Biology 2018 DOI: 10.1128/mcb.00051-18
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• Translationally controlled tumor protein (TCTP) is required for TGF-β1 induced epithelial to mesenchymal transition and influences cytoskeletal reorganization
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2018 DOI: 10.1016/j.bbamcr.2017.09.014
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• Transcriptome analysis of Aedes aegypti in response to mono-infections and co-infections of dengue virus-2 and chikungunya virus
  Biochemical and Biophysical Research Communications 2017 DOI: 10.1016/j.bbrc.2017.01.162
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