Thankhoe A. Rants'o
University of the Witwatersrand Johannesburg, Portland State University, National University of Lesotho
Research areas: Pharmacology, Toxicology and Pharmaceutics · Drug Discovery · Computational Drug Discovery Methods · Advanced Drug Delivery Systems · Malaria Research and Control
0000-0001-8585-0888
About
Dr. Rants'o is a Cancer Pharmacologist serving as an Assistant Professor of Pharmacology at the Presbyterian College School of Pharmacy. He completed his postdoctoral fellowship in cancer metastasis at the Huntsman Cancer Institute, College of Pharmacy, University of Utah.
Background: After his BPharm (Honors) degree from the National University of Lesotho (Maseru, Lesotho), Dr. Rants'o worked as a Pharmacist at Paray Mission Hospital (Lesotho). He then obtained a Fulbright Scholarship to pursue a master's degree in Medicinal Chemistry at the Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University (Alabama, USA). His MSc research focused on cancer metabolomics and natural product drug discovery. He further obtained a PhD in Pharmacology from the University of the Witwatersrand (Johannesburg, South Africa), where his research focused on infectious diseases. Following this, he joined the University of Utah (Utah, USA), Department of Pharmacology and Toxicology, and Huntsman Cancer Institute, as a postdoctoral research associate in cancer pharmacology. There, Dr. Rants'o consolidated his research niche in cancer metastasis; he focused on identifying tractable targets to block cancer metastasis, the principal cause of cancer-related death. He continues his metastasis research targeting protein kinases, the master regulators of cancer cell signaling.
Previous academic service: Dr. Rants’o previously served as a Pharmacology Lecturer at the University of the Witwatersrand (South Africa) for more than 5 years. He has supervised at least one PhD and three master's theses to completion. He has published various research papers and serves as a certified reviewer and guest editor for various research journals.
Employment
Employment history is unavailable.
Education
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University of the Witwatersrand Johannesburg PhD2018 - 2023
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Portland State University Intensive English Language Certificate2015 - 2015
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National University of Lesotho B. Pharm (Honours)2009 - 2014
Projects & Funding
Projects & funding information is unavailable.
Publications (30)
- In vitro and in silico antiviral activity of GC–MS-identified metabolites from three South African medicinal plants against H1N1 and SARS-CoV-2 Save
- The Design and Development of a Dexamethasone‐Tranfersome‐PF‐127/HA Stimuli‐Responsive Hydrogel for Intra‐Articular Therapy in Osteoarthritis Save
- Structure-Based Discovery of Orthosteric Non-Peptide GLP-1R Agonists via Integrated Virtual Screening and Molecular Dynamics Save
- Structure-Based Discovery of Orthosteric Non-Peptide GLP-1R Agonists via Integrated Virtual Screening and Molecular Dynamics Save
- Isoetin from Isoetaceae Exhibits Superior Pentatransferase Inhibition in Breast Cancer: Comparative Computational Profiling with FDA-Approved Tucatinib Save
- A Multifaceted Computational Approach to Identify PAD4 Inhibitors for the Treatment of Rheumatoid Arthritis (RA) Save
- Repurposing FDA-Approved Agents to Develop a Prototype Helicobacter pylori Shikimate Kinase (HPSK) Inhibitor: A Computational Approach Using Virtual Screening, MM-GBSA Calculations, MD Simulations, and DFT Analysis Save
- Targeting KRAS G12C and G12S Mutations in Lung Cancer: In Silico Drug Repurposing and Antiproliferative Assessment on A549 Cells Save
- Gallic Acid: A Potent Metabolite Targeting Shikimate Kinase in Acinetobacter baumannii Save
- Targeting Shikimate Kinase in Acinetobacter baumannii: Gallic Acid as a Potent Inhibitory Metabolite from FDA-Approved Drug Screening Save
- In silico analysis of the melamine structural analogues interaction with calcium-sensing receptor: A potential for nephrotoxicity Save
- A Micro-In-Macro Gastroretentive System for the Delivery of Narrow-Absorption Window Drugs Save
- Bioactivity of select essential oil constituents against life stages of Anopheles arabiensis (Diptera: Culicidae) Save
- In vitro and in silico analysis of the Anopheles anticholinesterase activity of terpenoids Save
- The insecticidal activity of essential oil constituents against pyrethroid-resistant Anopheles funestus (Diptera: Culicidae) Save
- Development of a Eudragit-Chitosan Nanosystem for the pH-Dependent Transport of Duloxetine to the Brain: Synthesis, Characterization and In Silico Modeling Analysis Save
- Evaluation of the in vitro Antibacterial and Antioxidant Activities, Cytotoxic Effects, and Phytochemical Screening of Root Extracts of Kedrostis capensis A. Meeuse and Trachyandra asperata Kunth. from Lesotho Save
- A Poly (Caprolactone)-Cellulose Nanocomposite Hydrogel for Transdermal Delivery of Hydrocortisone in Treating Psoriasis Vulgaris Save
- An Oral 3D Printed PLGA-Tocopherol PEG Succinate Nanocomposite Hydrogel for High-Dose Methotrexate Delivery in Maintenance Chemotherapy Save
- Biomedicine Innovations and Its Nanohydrogel Classifications Save