Saptarshi Roy
Indiana University School of Medicine, UPMC Children's Hospital of Pittsburgh Child Development Unit, Visva-Bharati, Visva-Bharati University, The University of Texas Health Science Center at Tyler
0000-0001-8750-9018
About
At present working on environmental factor like viral infection (CVB) converge at the β cell, the heightened ER stress generates PTM dependent neo-antigens through Ca2+-dependent enzymatic mechanisms. This leads to activation of β cell self-reactive T cells, destroying β cells and leading to diabetes in those individuals predisposed to autoimmunity.
In both human and murine models, research has focused on metabolic reprogramming to modify NK cell activities after microbial infection during postdoctoral research. To gain metabolic adaptability during TB infection, it is necessary to understand the function of nutrition receptors in NK cells.
I used natural product biochemistry during my PhD research to create anthelmintic substitutes for gastrointestinal parasites (Helminthiasis).
Employment
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Indiana University School of Medicine Assistant Research Professor of Medicine2026 - Present
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Indiana University School of Medicine Postdoctoral Research Associate2023 - 2026
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UPMC Children's Hospital of Pittsburgh Child Development Unit Postdoctoral Research Associate2022 - 2023
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The University of Texas Health Science Center at Tyler Postdoctoral Research Associate2019 - 2022
Education
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Visva-Bharati Ph.D.2013 - Present
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Visva-Bharati University Master in Zoology2009 - 2011
Projects & Funding
Projects & funding information is unavailable.
Publications (21)
- Soluble LAG-3 Identifies a Dynamic Early T Cell Activation Window in self-reactivity, Type 1 Diabetes, and Broader Immune Responses Save
- Preclinical evaluation of Senna alata leaf extract against Hymenolepis diminuta: a promising natural anthelmintic solution Save
- Decoding the metabolic checkpoints in helminths: Opportunities for novel anthelmintic drug development Save
- Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility Save
- Engineering sialylation in pigs: A promising strategy for overcoming xenograft rejection and revolutionizing organ transplantation Save
- Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of type 1 diabetes Save
- Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity Save
- Exploring Metabolic Disruption and Redox Modulation by Senna Leaf Extracts Induces Mortality in the Zoonotic Parasite Hymenolepis diminuta Save
- Decoding the immune dance: Unraveling the interplay between beta cells and type 1 diabetes Save
- DOCK2 Promotes Pleural Fibrosis by Modulating Mesothelial to Mesenchymal Transition Save