Ishfaq A. Ahanger

About

Primary research focus of Dr. Ishfaq is to investigate the dynamics of protein misfolding and aggregation, and their potential implications in protein conformational diseases (proteinopathies) especially neurodegenerative diseases. Furthermore, his research emphases is to develop the molecular modulators/inhibitors to target various kinds of protein aggregated species and formulate the efficient therapeutic agents for these diseases.

Research Area and Interest: Dynamics of protein folding, protein misfolding and protein aggregation, Proteo-metabolomics, Protein-drug and protein-protein interactions, Co-solute engineering, and Molecular biology. Nanoparticle and surfactant-induced modulation of protein aggregation and their implication in medicine.

Employment

• ICMR-DHR Young Scientist (Postdoctoral Fellow) ICMR-DHR Young Scientist (Postdoctoral Fellow)
  2022 - Present
• Jamia Millia Islamia Research Scholar
  2018 - 2022
• Amity University Gurugram Doctoral Scholar
  2016 - 2017
• Dolphin (P.G) Institute of Biomedical and Natural Sciences Research Trainee
  2015 - 2015

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (21)

• Glutamate binding perturbs structure-function integrity of carbonic anhydrase and promotes its aggregation: Implications of dysregulated metabolite levels in neurodegeneration
  International Journal of Biological Macromolecules 2026 DOI: 10.1016/j.ijbiomac.2026.152944
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• Nano-conjugation of small molecule modulators of protein aggregation: Enhancing the therapeutic precision
  International Journal of Biological Macromolecules 2025 DOI: 10.1016/j.ijbiomac.2025.148293
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• Impact of amino acid derivative osmolytes on structure-function integrity and aggregation propensity of catalase: Implications for inefficient antioxidant defense in protein aggregation disorders
  Journal of Molecular Liquids 2025 DOI: 10.1016/j.molliq.2025.127626
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• Neurometabolite, myo-inositol, induces conformational distortion with enhanced aggregation of Carbonic Anhydrase: Implications for altered metabolite levels in Alzheimer's disease
  Journal of Molecular Structure 2025 DOI: 10.1016/j.molstruc.2024.141054
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• Modulation of conformational integrity and aggregation propensity of α-synuclein by osmolytes: Implications in therapeutic intervention of Parkinson’s disease
  2025 DOI: 10.1016/bs.pmbts.2024.10.006
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• Small molecule inhibitors targeting alpha-synuclein aggregation: Progress and future outlook
  Advances in Protein Chemistry and Structural Biology 2025 DOI: 10.1016/bs.apcsb.2025.08.017
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• Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson's disease
  Ageing Research Reviews 2024 DOI: 10.1016/j.arr.2024.102538
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• Probing protein aggregation through spectroscopic insights and multimodal approaches: A comprehensive review for counteracting neurodegenerative disorders
  Heliyon 2024 DOI: 10.1016/j.heliyon.2024.e27949
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• Potential of Osmolytes as Diagnostic Biomarkers in Various Diseases
  Cellular Osmolytes from Chaperoning Protein Folding to Clinical Perspectives Second Edition 2024 DOI: 10.1007/978-981-97-6001-5_10
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• Diverse Biological Functions of Myo-inositol: A Neuro-Metabolite, Osmoprotectant, and Diagnostic Marker
  Cellular Osmolytes from Chaperoning Protein Folding to Clinical Perspectives Second Edition 2024 DOI: 10.1007/978-981-97-6001-5_9
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