0000-0001-9238-1477 About
I am a researcher based at the CSIR-Indian Institute of Chemical Biology (IICB) in Kolkata, working at the intersection of machine learning, supramolecular chemistry, and biotechnology to develop "digital-to-biological" feedback loops for advanced therapeutics. My work leverages artificial intelligence, particularly Protein Language Models like ProtBERT, to accelerate the de novo design and high-throughput screening of antimicrobial peptides targeting multidrug-resistant pathogens (such as MRSA) and targeted peptide-drug conjugates for oncology. Complementing this computational discovery, my research involves engineering machine learning-optimized supramolecular hydrogels and automated 3D bioprinting platforms to establish high-fidelity, animal-free organoid models for rapid therapeutic validation. By bridging data-driven in silico design with rigorous experimental translation, I am open to collaborating across clinical and industrial consortia to accelerate the pipeline from molecular concept to validated biological efficacy.
Keywords: Antimicrobial Peptides, Protein Language Models, ProtBERT, Supramolecular Hydrogels, 3D Bioprinting, Peptide-Drug Conjugates, Targeted Therapeutics.
Employment
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Indian Institute of Chemical Biology Scientist2022 - Present
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (20)
- Human Tat-derived cyclic peptide destabilizes the MALAT1 ENE triple helix and attenuates expression Save
- Dual-objective protein language model for discovery of non-hemolytic antimicrobial peptides from the bee-melectin sequence space Save
- Identification and Classification of Functional Split G-Quadruplexes Using Machine Learning-Guided Activity Screening Save
- Metal-free synthesis of N-fused quinazolino-quinazoline-diones as a MALAT1 RNA triple helix intercalator Save
- Peptidomimetic ligands regulate BCL-2 expression by stabilizing DNA secondary structures. Save
- G4 Sensing Pyridyl-Thiazole Polyamide Represses c-KIT Expression in Leukemia Cells. Save
- Anticancer activities of a heterocyclic molecule that selectively stabilizes G-quadruplex DNA. Save
- Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K+-ion across biological membranes. Save
- G-Quadruplex-Binding Small Molecule Induces Synthetic Lethality in Breast Cancer Cells by Inhibiting c-MYC and BCL2 Expression. Save
- Chemical Regulation of DNA i-Motifs for Nanobiotechnology and Therapeutics. Save