BP
Basant Patel
Indian Institute of Technology Hyderabad, University of Illinois at Chicago, Lab of Prof. Susan Liebman, Banaras Hindu University
0000-0001-9465-4803
Employment
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Indian Institute of Technology Hyderabad Professor2022 - Present
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Indian Institute of Technology Hyderabad Associate Professor2016 - 2022
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Indian Institute of Technology Hyderabad Assistant Professor2010 - 2016
Education
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University of Illinois at Chicago, Lab of Prof. Susan Liebman Post-Doctoral Research2004 - 2009
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Banaras Hindu University PhD2000 - 2004
Projects & Funding
Projects & funding information is unavailable.
Publications (35)
- Mechanistic Insights into Unfolding of the Mitochondrial Localization Sequence M1 of TDP-43 and Identification of a MAPKAPK2 Inhibitor as a potential binder of M1 for inhibition of TDP-43’s Aberrant Mitochondrial Localization Save
- Elucidating the conformational dynamics of the mitochondrial localization signal, M3, of TDP-43 and accessing potential binders using molecular docking and simulation Save
- Targeting oxidative stress to combat neurodegenerative diseases, amyotrophic lateral sclerosis and Huntington’s, for better brain health and recovery Save
- Elucidating the conformational dynamics of the mitochondrial localization signal, M3, of TDP-43 and accessing potential inhibitors using molecular docking and simulation Save
- Therapeutic targeting of the oxidative stress generated by pathological molecular pathways in the neurodegenerative diseases, ALS and Huntington's Save
- Enhanced in vitro aggregation, but not phase separation, of TDP-43 and its C-terminal fragments generates intrinsic deep-blue autofluorescence Save
- Activation of the yeast MAP kinase, Slt2, protects against TDP-43 and TDP-25 toxicity in the Saccharomyces cerevisiae proteinopathy model Save
- Enhancedin vitroaggregation, but not phase separation, of TDP-43 and its C-terminal fragments generate deep-blue autofluorescence Save
- Computational Insights Into the Mechanism of EGCG's Binding and Inhibition of the TDP‐43 Aggregation Save
- In silicoandin vitrostudies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies Save