SM
Stephen C. Mack
Also known as: Steve Mack
St. Jude Children's Research Hospital, Baylor College of Medicine, University of Toronto, Cleveland Clinic Research
Research areas: Medicine · Oncology · Glioma Diagnosis and Treatment · Chromatin Remodeling and Cancer · Genomics and Chromatin Dynamics
0000-0001-9620-4742
Employment
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St. Jude Children's Research Hospital Associate Member2021 - Present
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Baylor College of Medicine Assistant Professor2017 - Present
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Cleveland Clinic Lerner Research Institute Post-Doctoral Research Fellow2014 - 2017
Education
- 2006 - 2014
Projects & Funding
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Interrogating Chromatin States to Pinpoint the Cellular Origins and Therapeutic Targets in Pediatric Brain Tumours Cancer Prevention and Research Institute of Texas2017 - 2021
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Interrogating the enhancer landscape of ependymoma to inform novel therapies Alex's Lemonade Stand Foundation for Childhood Cancer2016 - 2019
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Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma Canadian Institutes of Health Research2012 - 2012
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Identification of novel ependymoma tumour suppressor genes by genome-wide DNA methylation profiling. Canadian Institutes of Health Research2010 - 2013
Publications (138)
- Nuclear Export as a Therapeutic Vulnerability in ZFTA-RELA Ependymoma Save
- A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance Save
- B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response Save
- Combined targeting of glioblastoma stem cells of different cellular states disrupts malignant progression Save
- Erratum: Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma (The Journal of experimental medicine (2019) 216 5 PII: e2019019605052025C DOI: 10.1084/jem.20190196.) Save
- Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding Save
- Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis Save
- Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis Save
- Targeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma Save
- ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip Save
- A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice Save
- A road map for the treatment of pediatric diffuse midline glioma Save
- An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma Save
- Dominant Malignant Clones Leverage Lineage Restricted Epigenomic Programs to Drive Ependymoma Development Save
- Histone serotonylation regulates ependymoma tumorigenesis Save
- IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages Save
- Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology Save
- Protocol for live-cell imaging of immune synapse formation and activation of CAR T cells against cancer cells Save
- TULIPs decorate the three-dimensional genome of PFA ependymoma Save
- The Intersection of Epigenetic Alterations and Developmental State in Pediatric Ependymomas Save