Monika Sharma

About

Bridging fundamental molecular insights with translational biomedical applications, my research explores how the dynamic behavior of biomolecules shapes regulatory mechanisms and drives therapeutic innovations. From understanding the fine-tuned control of gene expression to designing next-generation immunotherapeutics, this journey translates molecular interactions into actionable medical solutions.

Employment

• Plaksha University Associate Professor & Founding Faculty
  2023 - Present
• Plaksha University Asst. Professor & Founding Faculty
  2021 - 2023
• Indian Institute of Science Education and Research Mohali
  2015 - 2021

Education

• International Institute of Information Technology Hyderabad Center for Computational Natural Sciences and Bioinformatics PhD
  2007 - 2012

Projects & Funding

• Development of hepcidin targeted therapies for anemia ICMR
  2025 - 2028
• Solute transporters in NVU Department of Biotechnology
  2024 - 2027
• Cytokine structural engineering Science and Engineering Research Board
  2022 - 2025
• Sugar acid transcriptional regulators Department of Biotechnology, Ministry of Science and Technology, India
  2021 - 2024
• Investigations of molecular mechanism and dynamics of 3' SS recognition by SF1 and U2AF in humans Department of Science and Technology, Ministry of Science and Technology, India
  2020 - 2022
• In silico investigations of RNA-protein complexes DST INSPIRE
  2015 - 2020

Publications (32)

• Molecular mechanisms underlying allosteric behavior of Escherichia coli DgoR, a GntR/FadR family transcriptional regulator
  Nucleic Acids Research 2025 4 citations DOI: 10.1093/nar/gkae1299
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• Functional consequences of genetic variations in DgoR, a GntR/FadR family transcriptional repressor of D-galactonate metabolism in Escherichia coli
  Journal of Bacteriology 2025 0 citations DOI: 10.1128/jb.00103-25
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• Splicing of branchpoint-distant exons is promoted by Cactin, Tls1 and the ubiquitin-fold-activated Sde2
  Nucleic Acids Research 2022 9 citations DOI: 10.1093/nar/gkac769
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• Probing Nanoscale Lipid–Protein Interactions at the Interface of Liquid Crystal Droplets
  Nano Letters 2021 30 citations DOI: 10.1021/acs.nanolett.0c05139
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• Molecular insights into effector binding by DgoR, a GntR/FadR family transcriptional repressor of D‐galactonate metabolism in Escherichia coli
  Molecular Microbiology 2021 15 citations DOI: 10.1111/mmi.14625
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• A Comprehensive Analysis of cis-Acting RNA Elements in the SARS-CoV-2 Genome by a Bioinformatics Approach.
  Frontiers in genetics 2020 25 citations DOI: 10.3389/fgene.2020.572702
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• Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one-carbon metabolism
  Journal of Biological Chemistry 2020 40 citations DOI: 10.1074/jbc.ra120.015129
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• Investigating the pathogenic SNPs in BLM helicase and their biological consequences by computational approach
  Scientific Reports 2020 35 citations DOI: 10.1038/s41598-020-69033-8
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• Understanding the binding specificities of mRNA targets by the mammalian Quaking protein
  Nucleic Acids Research 2019 12 citations DOI: 10.1093/nar/gkz877
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• In silico characterization of residues essential for substrate binding of human cystine transporter, xCT
  Journal of Molecular Modeling 2019 4 citations DOI: 10.1007/s00894-019-4233-y
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