Garima Rani
Indian Institute of Technology Delhi, Indraprastha Institute of Information Technology Delhi, Institute of Mathematical Sciences, Friedrich Schiller University Jena
0000-0002-0105-0590
About
I am a biophysicist, working to understand biology with a interdisciplinary and holistic viewpoint, utilising computational and theoretical tools combined with experiments, to address vexing public health concerns and ecological challenges. I work primarily on understanding bacterial resilience from single cell to colony scale. During my PhD, I worked on understanding the design principles underpinning the stability of the cell wall of bacteria and to model the action of biomimetic antimicrobial agents on the bacterial cell membrane, using theoretical and computational methods. In 2021, I moved to Luxembourg as a HFSP fellow at University of Luxembourg (Lab of Prof. Anupam Sengupta). I investigated spatiotemporal evolution of genealogical enclaves in growing single cell founder colonies and quantified the effect of biological activity on mixing-demixing dynamics, using a combination of theoretical, computational and microbiology experimental techniques. Currently, I am in Institut für Mikrobiologie, Friedrich Schiller University Jena (Lab of Prof. Rosalind Allen), working towards understanding the molecular and biophysical basis for high level resistance in bacteria and origin of growth and division rules followed in bacterial cell cycle.
Webpage: https://sites.google.com/view/garimarani/
My primary research interests include -
1- Design principles and mechanical stability of bacterial cell envelope.
3- Antibacterial action on the bacterial cell envelope.
4- Protein self assembly.
5- Understanding hotspots of biological activity in microbial colonies.
6- Molecular mechanisms to understand antimicrobial resistance.
Employment
-
Indian Institute of Technology Delhi Assistant Professor2025 - Present
-
Indraprastha Institute of Information Technology Delhi Assistant Professor2025 - 2025
-
Friedrich Schiller University Jena HFSP Cross-Disciplinary Fellow2024 - 2025
-
University of Luxembourg HFSP Cross-Disciplinary Fellow2021 - 2023
-
Tata Centre for Interdisciplinary Sciences Postdoctoral Fellow2021 - 2021
Education
-
Institute of Mathematical Sciences PhD2015 - 2020
Projects & Funding
Projects & funding information is unavailable.
Publications (12)
- Substrate stiffness governs dynamics and self-organization of nascent biofilms Save
- Bacterial Adhesion on Soft Surfaces: The Dual Role of Substrate Stiffness and Bacterial Growth Stage Save
- Substrate stiffness modulates bacterial adhesion and diversity of adherent phenotypes across growth stages Save
- Activity-driven emergence of genealogical enclaves in growing bacterial colonies Save
- Role of Lipid Packing Defects in Determining Membrane Interactions of Antimicrobial Polymers Save
- The function of peptide-mimetic anionic groups and salt bridges in the antimicrobial activity and conformation of cationic amphiphilic copolymers Save
- Towards designing globular antimicrobial peptide mimics: role of polar functional groups in biomimetic ternary antimicrobial polymers Save
- Aggregation of methacrylate-based ternary biomimetic antimicrobial polymers in solution. Save
- Modeling heterogeneities in the crosslinked bacterial sacculus Save
- Importance of being cross-linked for the bacterial cell wall Save