Florian Bach
Stanford University, University of Edinburgh, University of Glasgow
Research areas: Immunology and Microbiology · Immunology · Malaria Research and Control · T-cell and B-cell Immunology · Bird parasitology and diseases
0000-0002-0126-5516
About
I'm a molecular infection biologist by training, but shifted my focus from the pathogen to the host for my PhD. My thesis project examined both falciparum and vivax malaria using controlled human re-infection models. Key techniques I use are flow and mass cytometry, as well as bulk and single cell RNAseq. My work experience and expertise range from experimental design and optimisation to sample collection and processing to bioinformatic and statistical analysis, guided by the biological question I'm interested in.
Employment
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Stanford University Postdoctoral Scholar2022 - Present
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University of Edinburgh Postdoctoral Research Associate2021 - 2022
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The University of Edinburgh Postgraduate Demonstrator2018 - 2021
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University of Glasgow Research Technician2016 - 2016
Education
- 2017 - 2021
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University of Edinburgh MRes in "Hosts, Pathogens and Global Health", with Merit2016 - 2017
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University of Glasgow BSc (Hons) in Virology, First Class2012 - 2016
Projects & Funding
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University of Edinburgh - Hosts, Pathogens & Global Health Wellcome Trust2016 - 2020
Publications (18)
- Immune trajectories enable detection of asymptomatic parasitemia and predict future malaria outcomes Save
- Assessing the Effect of Malaria Exposure History on Tetanus Antibody Waning Rates Among Children in Jinja and Tororo Districts, Uganda Save
- Prenatal immune priming to Plasmodium falciparum is characterized by multi-lineage T-cell responses that are influenced by maternal microchimerism and predict malaria outcomes Save
- Low Birthweight and Prematurity, but not Malaria Chemoprevention, Are Associated With Reduced Pneumococcal Vaccine Immunogenicity in Ugandan Infants Save
- Exposure to P. falciparum and common cold viruses shape vaccine responses in early life Save
- CXCR6+CD127- Tr1 cells balance immunity and persistence in Plasmodium falciparum infection. Save
- Cytotoxic Vδ2+ T cell subsets expand in response to malaria in human tonsil and spleen organoids. Save
- Maternal malaria and early-life infections shape humoral immunity to P. falciparum in infants Save
- Development of clinical immunity to Plasmodium vivax following repeat controlled human malaria infection Save
- Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection Save
- Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses Save
- Moving beyond discovery science to a mechanistic understanding of human malaria. Save
- Natural killer cell antibody-dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission. Save
- A systematic analysis of the human immune response to Plasmodium vivax Save
- Repeat controlled human malaria infection of healthy UK adults with blood-stage Plasmodium falciparum: Safety and parasite growth dynamics. Save
- Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly Save
- isolating human malaria parasites for RNA-sequencing at ultra-low densities v1 Save
- Senescence in immunity against helminth parasites predicts adult mortality in a wild mammal Save